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Peptidoglycan biosynthesis is regulated by a feedback mechanism preventing the pathway from sequestering essential lipid carriers used to assemble and transport surface glycan subunits.
GWAS in difficult-to-recruit populations identifies variants associated with Lassa fever outcome and susceptibility at loci proximal to LIF, GRM7 and LARGE1.
Rhesus macaques are susceptible to oral challenge of human noroviruses and can be used as a model to recapitulate infection and adaptive immune responses in humans.
Philip Poole narrates his career story and his motivations for studying rhizobia, the agriculturally important bacterial plant symbiont responsible for fixing nitrogen.
Training and funding for mentoring, together with metrics to measure success, can ensure this vital practice is beneficial for all mentees, at all stages of their career, argues Michal Elovitz.
Metabolomics and feeding experiments demonstrate the host’s active role in sharing organic acids with a gut microbiota member, revealing host–microbe interactions that foster symbiosis.
Sensing of brain glucose by the fungal pathogen Cryptococcus neoformans alters lipid metabolism and membrane composition in the fungus, rendering it drug tolerant.
A trait-based approach harnesses the vast amount of microbial genomic data and enables integration with biogeochemical models, predicting soil microbial ecology and physiology without the need for cultures.
Automated and scalable designation of virus lineages based on a heuristic approach can help to determine and curate virus lineages from large genomic datasets and inform nomenclature.
Tc toxins of Yersinia entomophaga are assembled only in a subpopulation of cells, followed by a suicide mechanism that results in the release of the toxins.
The gut virome is altered in a mouse model of chronic stress and is associated with changes in behavioural and immune response, which can be restored using faecal virome transfer.
Isotope tracing, kinetics and transcriptomics show how members of the four AOM lineages employ different nitrogen use strategies that minimize competition for nitrogen substrates.