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A novel bright near-infrared fluorescent protein inserted into a nanobody enables visualization of native proteins inside living cells and specific manipulation of cell function, including Boolean protein-based operators.
DiMeLo-seq leverages immunotethered DNA methyltransferases with long-read sequencing to map the locations of chromatin proteins in their natural context.
A novel approach to probabilistically align adjacent multiple tissue slices from spatially resolved transcriptomics data provides unprecedented depth for the investigation of tissue architecture and paves the way for new developments in 3D spatial analytics.
A flexible open-top light-sheet microscope has been developed that can perform deep three-dimensional imaging on all clearing protocols with low and high optical resolution.
Two new toolkits that leverage deep-learning approaches can track the positions of multiple animals and estimate poses in different experimental paradigms.
Engineered viral entry combined with single-cell sequencing technology makes it possible to identify specific ligand–receptor interactions in a high-throughput manner.
Global profiling of changes in the reactivity of cysteine residues in response to phosphorylation during mitosis identifies cysteine residues as potential regulatory and drug binding sites on proteins.
A droplet microfluidic system enables deterministic capture and subsequent sequencing and analysis of single-cell transcriptomes from organoids and other small, individual tissue samples.
Cryofixation-based ultrastructure-expansion microscopy (cryo-ExM) bypasses artifacts caused by chemical fixation and establishes more-native preservation of biological samples.
Software solutions pGlyco3 and StrucGP both aim to better assign the glycan part of a glycopeptide beyond simple glycosyl composition, but they differ in their strategies, their requirement for a glycan library and their applicability to O-glycopeptides.
The MISpheroID knowledgebase records and organizes experimental parameters from thousands of cancer spheroid experiments, revealing heterogeneity and a lack of transparency in key spheroid research reporting practices.
Technological innovations in optical object recognition and high-throughput ultrasensitive mass spectrometry are enabling subcellular metabolomics and peptidomics, providing unprecedented opportunities to study small-molecule mediators of cellular function with important implications in health and disease.
Dynamic mass photometry, a method based on optical imaging of unlabeled proteins, enables direct observation and tracking of single-protein interactions on lipid membranes.
A four-dimensional single-cell atlas of transcription factor expression in Caenorhabditis elegans allows the identification of novel regulators of embryo development and the generation of molecular models of cell fate specification.
