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Structural biology

Using evolution to predict structure

Researchers use sequence coevolution information to predict the structures of protein complexes.

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References

  1. Hopf, T.A. et al. Sequence co-evolution gives 3D contacts and structures of protein complexes. eLife 3, e03430 (2014).

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  2. Ovchinnikov, S. et al. Robust and accurate prediction of residue-residue interactions across protein interfaces using evolutionary information. eLife 3, e02030 (2014).

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Doerr, A. Using evolution to predict structure. Nat Methods 11, 1192–1193 (2014). https://doi.org/10.1038/nmeth.3198

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