Regenerative medicine: Noodle gels for cells

Journal name:
Nature Materials
Volume:
9,
Pages:
535–536
Year published:
DOI:
doi:10.1038/nmat2789

Heating and cooling of peptide amphiphile suspensions converts disorganized nanofibres into liquid-crystalline nanofibre bundles that gel on addition of salts. The noodle-shaped strings of gel can entrap and align cells.

At a glance

Figures

  1. A schematic of cell growth on synthetic engineered scaffolds made by different routes.
    Figure 1: A schematic of cell growth on synthetic engineered scaffolds made by different routes.

    a, An implantable scaffold with microporous aligned tubes in which cells orient randomly within tubes as a result of the large size of the void. b, An electrospun scaffold with aligned nanofibres in which cells adhere to the outside of the scaffold but cannot penetrate because of the small mesh size. c, An aligned nanofibre gel scaffold where cells are incorporated within the scaffold directly. The magnification shows a single cell aligned on a string (the arrow indicates alignment direction).

  2. A schematic of the thermal process to form liquid-crystalline nanofibre bundles.
    Figure 2: A schematic of the thermal process to form liquid-crystalline nanofibre bundles.

    a–c, Randomly oriented individual nanofibres (a) assemble into plaque-like plates (b) on heating. Cooling of the plates results in the formation of an aligned liquid-crystalline phase of nanofibre bundles (c).

References

  1. http://en.wikipedia.org/wiki/La_mian
  2. Larson, R. The Structure and Rheology of Complex Fluids (Topics in Chemical Engineering, Oxford Univ. Press, 1999).
  3. Zhang, S. et al. Nature Mater. 9, 594601 (2010).
  4. Engel, E. et al. Trends Biotechnol. 26, 3947 (2007).
  5. Merzlyak, A., Indrakanti, S. & Lee, S. W. Nano Lett. 9, 846852 (2009).
  6. Hartgerink, J. D., Beniash, E. & Stupp, S. I. Proc. Natl Acad. Sci. USA 99, 51335138 (2002).
  7. Lutolf, M. P. & Hubbell, J. A. Nature Biotechnol. 23, 4755 (2005).
  8. de las Heras Alarcón, C., Pennadam, S. & Alexander, C. Chem. Soc. Rev. 34, 276285 (2005).

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Author information

Affiliations

  1. Timothy J. Deming is in the Department of Bioengineering, 5121 Engineering 5, University of California, Los Angeles, California 90095, USA.
    demingt@seas.ucla.edu

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