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Volume 9 Issue 5, May 2003

Ancient scourges have plagued humankind for centuries. There remains an urgent need to improve the efficacy of the live tuberculosis vaccine, Mycobacterium bovis BCG (bacillus Calmette-Guérin). Pym et al. reintroduced into the BCG strain genes encoding proteins that induce potent Th1 responses and subsequently better protect against virulent M. tuberculosis challenge (page 533). The cover image is a stylized electron micrograph of a macrophage engulfing M. tuberculosis bacteria. Magnification, ×2,000. On page 525, Krutzik et al. describe the regulation of Toll-like receptors in another ancient human scourge, leprosy.

Volume 9 Issue 5

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Editorial

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Commentary

  • S-nitroso-hemoglobin (SNOHb) has been proposed to regulate blood flow and tissue oxygenation through allosterically controlled binding and delivery of nitric oxide (NO) and oxygen in the vasculature. This precept and the experiments that test it have provoked both ardent support and expanding dissent. An alternative view suggests that a physiologically tightly regulated balance of NO scavenging by hemoglobin and NO production by endothelial cells determines NO bioavailability.

    • Mark T. Gladwin
    • Jack R. Lancaster Jr.
    • Alan N. Schechter
    Commentary
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Book Review

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News & Views

  • Restoration of genes lost during the original attenuation of the commonly used BCG tuberculosis vaccine enhances the ability of a recombinant strain to protect against Mycobacterium tuberculosis.

    • Douglas B. Young
    News & Views

  • Transplantation carries the risk of Kaposi sarcoma, which afflicts 1 out of 200 transplant recipients in the United States. An analysis of human post-transplant tumors indicates that the disease can originate from donor cells, highlighting the need for organ pre-screening.

    • Patrick S. Moore
    News & Views

  • Three new studies examine how a regulator of calcium homeostasis contributes to heart failure in humans and mice.

    • Kenneth R. Chien
    • John Ross Jr.
    • Masahiko Hoshijima
    News & Views

  • The evaluation of drug combinations for cancer treatment has progressed slowly through methodical clinical research. A new study examining gene expression profiles could signal a shift in the approach to combination therapy.

    • Todd R. Golub
    News & Views

  • Cells of the innate immune system get energy almost entirely from glycolysis, enabling survival under a variety of harsh conditions. The transcriptional regulator HIF-1 is now placed at the center of metabolic control in these cells.

    • Robert M. Strieter
    News & Views

  • Epigenetic suppression of FANCF, a member of the Fanconi anemia gene family, is now implicated in some ovarian cancers. Might this suppression explain the sensitivity of such cancers to the cross-linking agent cisplatin (pages 568–574)?

    • Grover C. Bagby
    • Susan B. Olson
    News & Views

    • Charlotte Schubert
    • Pierrette Lo
    News & Views
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