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Building a better tuberculosis vaccine

Restoration of genes lost during the original attenuation of the commonly used BCG tuberculosis vaccine enhances the ability of a recombinant strain to protect against Mycobacterium tuberculosis.

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Figure 1: RD1: on the cusp of virulence and protective immunity.

Kimberly Homer

References

  1. Pym, A.S. et al. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat. Med. 9; advance online publication 7 April 2003; doi:10.1038/nm859.

  2. Lewis, K.N. et al. Deletion of RD1 from Mycobacterium tuberculosis mimics Bacille Calmette-Guérin attenuation. J. Infect. Dis. 183, 117–123 (2003).

    Article  Google Scholar 

  3. Pym, A.S., Brodin, P., Brosch, R., Huerre, M. & Cole, S.T. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol. Microbiol. 46, 709–712 (2002).

    Article  CAS  Google Scholar 

  4. Chapman, A.L. et al. Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells. AIDS 16, 2285–2293 (2002).

    Article  Google Scholar 

  5. Brandt, L., Elhay, M., Rosenkrands, I., Lindblad, E.B. & Andersen, P. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect. Immun. 68, 791–795 (2000).

    Article  CAS  Google Scholar 

  6. Renshaw, P.S. et al. Conclusive evidence that the major T-cell antigens of the M. tuberculosis complex form a tight 1:1 complex and characterisation of the structural properties of ESAT-6, CFP-10 and the ESAT-6-CFP-10 complex: implications for pathogenesis and virulence. J. Biol. Chem. 277, 21598–21603 (2002).

    Article  CAS  Google Scholar 

  7. Horwitz, M.A., Harth, G., Dillon, B.J. & Maslesa-Galic, S. Recombinant Bacillus Calmette-Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc. Natl. Acad. Sci. USA 97, 13853–13858 (2000).

    Article  CAS  Google Scholar 

  8. Cole, S.T. et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537–544 (1998).

    Article  CAS  Google Scholar 

  9. Gey Van Pittius, N.C. et al. The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria. Genome Biol. 2, 1–18 (2001).

    Article  Google Scholar 

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Young, D. Building a better tuberculosis vaccine. Nat Med 9, 503–504 (2003). https://doi.org/10.1038/nm868

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