Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mastering innate immunity

Nature Medicine volume 9, pages 512–513 (2003)Cite this article

Cells of the innate immune system get energy almost entirely from glycolysis, enabling survival under a variety of harsh conditions. The transcriptional regulator HIF-1 is now placed at the center of metabolic control in these cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Metabolism and myeloid cells.

Kimberly Homer

References

  1. Medzhitov, R. & Janeway, C. Innate immunity. N. Engl. J. Med. 343, 338–344 (2000).

    Article  CAS  Google Scholar 

  2. Delves, P.J. & Roitt, I.M. The immune system. First of two parts. N. Engl. J. Med. 343, 37–49 (2000).

    Article  CAS  Google Scholar 

  3. Saadi, S., Wrenshall, L.E. & Platt, J.L. Regional manifestations and control of the immune system. FASEB J. 16, 849–856 (2002).

    Article  CAS  Google Scholar 

  4. Kempner, W. The nature of leukemic blood cells as determined by their metabolism. J. Clin. Invest. 18, 291–300 (1939).

    Article  CAS  Google Scholar 

  5. Borregaard, N. & Herlin, T. Energy metabolism of human neutrophils during phagocytosis. J. Clin. Invest. 70, 550–557 (1982).

    Article  CAS  Google Scholar 

  6. Kellett, D.N. 2-deoxyglucose and inflammation. J. Pharm. Pharmacol. 18, 199–200 (1966).

    Article  CAS  Google Scholar 

  7. Cramer, T. et al. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112, 645–657 (2003).

    Article  CAS  Google Scholar 

  8. Semenza, G.L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell. Dev. Biol. 15, 551–578 (1999).

    Article  CAS  Google Scholar 

  9. Semenza, G. Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 64, 993–998 (2002).

    Article  CAS  Google Scholar 

  10. Semenza, G.L. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med. 7, 345–350 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Pathology and Laboratory Medicine, Division of Pulmonary and Critical Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA

    Robert M. Strieter

Authors
  1. Robert M. Strieter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Strieter, R. Mastering innate immunity. Nat Med 9, 512–513 (2003). https://doi.org/10.1038/nm0503-512

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0503-512

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing