New evidence in mouse models reveals that exposure to Δ9-tetrahydrocannabinol (THC), the main psychoactive component in Cannabis sativa, might improve cognitive performance in aging animals.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
US National Institute on Drug Abuse. Marijuana (NIDA, 2017); available at https://www.drugabuse.gov/publications/research-reports/marijuana.
European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2016: Trends and Developments (Publications Office of the European Union, Luxembourg, 2016).
Morena, M. & Campolongo, P. Neurobiol. Learn. Mem. 112, 30–43 (2014).
Ledent, C. et al. Science 283, 401–404 (1999).
Bilkei-Gorzo, A. et al. Nat. Med. 23, 782–787 (2017).
Gaoni, Y. & Mechoulam, R. J. Am. Chem. Soc. 86, 1646–1647 (1964).
Zanettini, C. et al. Front. Behav. Neurosci. 5, 57 (2011).
Ferrer, I. Prog. Neurobiol. 97, 38–51 (2012).
Aso, E., Sánchez-Pla, A., Vegas-Lozano, E., Maldonado, R. & Ferrer, I. J. Alzheimers Dis. 43, 977–991 (2015).
Dubal, D.B. et al. J. Neurosci. 35, 2358–2371 (2015).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Ozaita, A., Aso, E. The cannabis paradox: when age matters. Nat Med 23, 661–662 (2017). https://doi.org/10.1038/nm.4348
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4348