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Basophils from humans with systemic lupus erythematosus do not express MHC-II

Nature Medicine volume 18, pages 488–489 (2012)Cite this article

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To the Editor:

Recently, Charles et al.1 demonstrated that basophils are able to promote antibody production and aggravate lupus nephritis. Furthermore, they demonstrate that human basophils express major histocompatibility complex class II (MHC-II).

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Figure 1: CD123+CD304− basophils from subjects with lupus do not express HLA-DR and express CD203c at variable levels.

References

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Acknowledgements

This work was supported by the German Research Foundation (SFB587 (TP14) and HA2791-3).

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Authors and Affiliations

  1. Department of Pediatric Immunology, Allergology and Pneumology, Hannover Medical School, Hannover, Germany

    Dorothea Dijkstra, Christian Hennig & Gesine Hansen

  2. Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany

    Torsten Witte

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  1. Dorothea Dijkstra
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  2. Christian Hennig
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  3. Torsten Witte
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  4. Gesine Hansen
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Correspondence to Dorothea Dijkstra.

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Dijkstra, D., Hennig, C., Witte, T. et al. Basophils from humans with systemic lupus erythematosus do not express MHC-II. Nat Med 18, 488–489 (2012). https://doi.org/10.1038/nm.2663

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