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| A series of articles highlighting the major biomedical achievements of the past decade. |
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| Editorial | Top |
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Look before you leap p553
doi:10.1038/nm0604-553
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| News | Top |
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Shift in NIH focus fuels basic researchers' fears p555
Alan Dove
doi:10.1038/nm0604-555a
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(344K)
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Europe's clinical trial database criticized p555
Xavier Bosch
doi:10.1038/nm0604-555b
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Newly expanded European Union faces growing pains p556
Peter Vermij
doi:10.1038/nm0604-556a
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(153K)
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Biomedical research budget comes up short down under p556
Carina Dennis
doi:10.1038/nm0604-556b
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(153K)
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Japan's laws on recombinant DNA tie researchers' hands p557
David Cyranoski
doi:10.1038/nm0604-557a
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(156K)
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Lax security at 'hot' labs draws fire p557
Tinker Ready
doi:10.1038/nm0604-557b
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(156K)
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Animal activists take aim at Columbia University's primate program p558
Bruce Diamond
doi:10.1038/nm0604-558a
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(255K)
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Collaboration may be the cure for what ails drug development p558
Amy K Erickson
doi:10.1038/nm0604-558b
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(255K)
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News In Brief p559
doi:10.1038/nm0604-559
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(212K)
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Profile: Yusuke Nakamura p560
Apoorva Mandavilli
doi:10.1038/nm0604-560
Abstract | Full text | PDF
(113K)
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| Correspondence | Top |
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PET concerns in bevacizumab treatment p561
Carsten Goessl
& Zarko Grozdanovic
doi:10.1038/nm0604-561a
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(244K)
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Reply to "PET concerns in bevacizumab treatment" p561
Christopher G Willett, Daniel Duda, Alan Fischman
& Rakesh K Jain
doi:10.1038/nm0604-561b
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(244K)
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| Commentaries | Top |
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Modern science versus the stigma of obesity pp563 - 569
Jeffrey M Friedman
doi:10.1038/nm0604-563
Abstract | Full text | PDF
(862K)
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When are research risks reasonable in relation to anticipated benefits? pp570 - 573
Charles Weijer
& Paul B Miller
doi:10.1038/nm0604-570
Abstract | Full text | PDF
(96K)
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| Book Review | Top |
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Alchemy of aging p575
Reviewed by: Tom B L Kirkwood
doi:10.1038/nm0604-575
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(152K)
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| News and Views | Top |
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Selecting the right patient for tumor therapy pp577 - 578
Carlos L Arteaga
doi:10.1038/nm0604-577
Abstract | Full text | PDF
(299K)
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TORward AKTually useful mouse models pp579 - 580
Ingo K Mellinghoff
& Charles L Sawyers
doi:10.1038/nm0604-579
Abstract | Full text | PDF
(761K)
See also: Article by Majumder et al. |
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Targeting tumors: seeing the light p580
Charlotte Schubert
doi:10.1038/nm0604-580
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(122K)
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Magic bullets melt fat pp581 - 582
Marc L Reitman
doi:10.1038/nm0604-581
Abstract | Full text | PDF
(423K)
See also: Article by Kolonin et al. |
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The two-timing thyroid pp582 - 583
Stephen B Liggett
doi:10.1038/nm0604-582
Abstract | Full text | PDF
(464K)
See also: Letter by Scanlan et al. |
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Balancing muscle hypertrophy and atrophy pp584 - 585
Eric P Hoffman
& Gustavo A Nader
doi:10.1038/nm0604-584
Abstract | Full text | PDF
(177K)
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Tolerance tag team pp585 - 587
Matthias von Herrath
& Dirk Homann
doi:10.1038/nm0604-585
Abstract | Full text | PDF
(120K)
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Cheating death in the liver pp587 - 588
M Eugenia Guicciardi
& Gregory J Gores
doi:10.1038/nm0604-587
Abstract | Full text | PDF
(2,384K)
See also: Article by Eichhorst et al. |
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Research notes p589
doi:10.1038/nm0604-589
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(103K)
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| Brief Communication | Top |
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PrPSc accumulation in myocytes from sheep incubating natural scrapie pp591 - 593
O Andréoletti, S Simon, C Lacroux, N Morel, G Tabouret, A Chabert, S Lugan, F Corbière, P Ferré, G. Foucras, H. Laude, F. Eychenne, J Grassi
& F Schelcher
Published online: 23 May 2004 | doi:10.1038/nm1055
Abstract | Full text | PDF
(657K)
| Supplementary Information |
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| Articles | Top |
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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways pp594 - 601
Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane
& William R Sellers
Published online: 23 May 2004 | doi:10.1038/nm1052
Abstract | Full text | PDF
(3,357K)
| Supplementary Information
See also: News and Views by Mellinghoff & Sawyers |
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Suramin inhibits death receptor−induced apoptosis in vitro and fulminant apoptotic liver damage in mice pp602 - 609
Sören T Eichhorst, Andreas Krueger, Susanne Müerköster, Stefanie C Fas, Alexander Golks, Uwe Gruetzner, Louise Schubert, Christine Opelz, Manfred Bilzer, Alexander L Gerbes
& Peter H Krammer
Published online: 16 May 2004 | doi:10.1038/nm1049
Abstract | Full text | PDF
(1,336K)
| Supplementary Information
See also: News and Views by Guicciardi & Gores |
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cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury pp610 - 616
Damien D Pearse, Francisco C Pereira, Alexander E Marcillo, Margaret L Bates, Yerko A Berrocal, Marie T Filbin
& Mary Bartlett Bunge
Published online: 23 May 2004 | doi:10.1038/nm1056
Abstract | Full text | PDF
(3,484K)
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Selective inhibition of NF- B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo pp617 - 624
Eijiro Jimi, Kazuhiro Aoki, Hiroaki Saito, Fulvio D'Acquisto, Michael J May, Ichiro Nakamura, Testuo Sudo, Takefumi Kojima, Fujio Okamoto, Hidefumi Fukushima, Koji Okabe, Keiichi Ohya
& Sankar Ghosh
Published online: 23 May 2004 | doi:10.1038/nm1054
Abstract | Full text | PDF
(1,932K)
| Supplementary Information |
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Reversal of obesity by targeted ablation of adipose tissue pp625 - 632
Mikhail G Kolonin, Pradip K Saha, Lawrence Chan, Renata Pasqualini
& Wadih Arap
Published online: 09 May 2004 | doi:10.1038/nm1048
Abstract | Full text | PDF
(2,853K)
| Supplementary Information
See also: News and Views by Reitman |
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| Letters | Top |
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Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein pp633 - 637
Xiao Yan Zhou, Nobuyuki Shibusawa, Karuna Naik, Delia Porras, Karla Temple, Hesheng Ou, Kelly Kaihara, Michael W Roe, Matthew J Brady
& Fredric E Wondisford
Published online: 16 May 2004 | doi:10.1038/nm1050
Abstract | Full text | PDF
(519K)
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3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone pp638 - 642
Thomas S Scanlan, Katherine L Suchland, Matthew E Hart, Grazia Chiellini, Yong Huang, Paul J Kruzich, Sabina Frascarelli, Dane A Crossley II, James R Bunzow, Simonetta Ronca-Testoni, Emil T Lin, Daniel Hatton, Riccardo Zucchi
& David K Grandy
Published online: 16 May 2004 | doi:10.1038/nm1051
Abstract | Full text | PDF
(268K)
| Supplementary Information
See also: News and Views by Liggett |
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| Technical Report | Top |
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Bioluminescent imaging of Cdk2 inhibition in vivo pp643 - 648
Guo-Jun Zhang, Michal Safran, Wenyi Wei, Erik Sorensen, Peter Lassota, Nikolai Zhelev, Donna S Neuberg, Geoffrey Shapiro
& William G Kaelin Jr
Published online: 02 May 2004 | doi:10.1038/nm1047
Abstract | Full text | PDF
(1,598K)
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| Errata | Top |
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ERRATUM: Adiponectin acts in the brain to decrease body weight p649
Yong Qi, Nobuhiko Takahashi, Stanley M Hileman, Hiralben R Patel, Anders H Berg, Utpal B Pajvani, Philipp E Scherer
& Rexford S Ahima
doi:10.1038/nm0604-649a
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(51K)
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ERRATUM: Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease p649
Miriam Merad, Petra Hoffmann, Erik Ranheim, Sarah Slaymaker, Markus G Manz, Sergio A Lira, Israel Charo, Donald N Cook, Irving L Weissman, Samuel Strober
& Edgar G Engleman
doi:10.1038/nm0604-649b
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(51K)
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| Corrigendum | Top |
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CORRIGENDUM: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer p649
Christopher G Willett, Yves Boucher, Emmanuelle di Tomaso, Dan G Duda, Lance L Munn, Ricky T Tong, Daniel C Chung, Dushyant V Sahani, Sanjeeva P Kalva, Sergey V Kozin, Mari Mino, Kenneth S Cohen, David T Scadden, Alan C Hartford, Alan J Fischman, Jeffrey W Clark, David P Ryan, Andrew X Zhu, Lawrence S Blaszkowsky, Helen X Chen, Paul C Shellito, Gregory Y Lauwers
& Rakesh K Jain
doi:10.1038/nm0604-649c
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(51K)
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| New on the Market | Top |
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New on the market p651
doi:10.1038/nm0604-651
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(100K)
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