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Causal machine learning methods could be used to predict treatment outcomes for subgroups and even individual patients; this Perspective outlines the potential benefits and limitations of the approach, offering practical guidance for appropriate clinical use.
Self-care interventions have the potential to improve health coverage for women while offering greater agency and autonomy, but only if certain barriers—such as stigma and cost—can be overcome.
The unique risks and needs of women in relation to noncommunicable diseases offer myriad opportunities to intervene and prevent disease, but several key barriers to implementation must be addressed.
The current definition of myocardial infarction is applied inconsistently, with implications for patients and research; here, the authors propose a new definition and call for further research and consensus.
The recently completed NCI-MATCH is one of the largest precision oncology trials undertaken to date; this Perspective discusses key aspects of its design and conduct, and lessons for future precision oncology studies.
The health sector must play its part in decarbonization efforts; this Perspective outlines the principles of fair pathways to net-zero healthcare that are attentive to health and socioeconomic inequalities.
This Perspective outlines practical considerations for designing and testing visual displays to communicate health information, using illustrative case examples.
The authors describe a localized toxicity syndrome that is associated with immunotherapy treatment for CNS tumors and propose a new grading scale—with the goal of promoting research and standardizing both reporting and management.
Moving away from the traditional ‘tumor-centric’ view, the authors explore how systemic biology, as well as aging, co-morbidities and co-medications, all interact and influence cancer development and progression.
Technological advances are transforming evidence generation in medicine; for these advances to impact public health, the clinical trial landscape must evolve and adapt to keep pace.
This Perspective outlines how cell atlases can provide the missing links between genes, diseases and therapies, with advances already being made in several fields, including COVID-19 and cancer.
This Perspective delivers an introduction to syndemic thinking, and provides insights into how epidemics interact and what scientists, clinicians and policymakers can do with this information.
The authors propose a new conceptual model of critical illness that moves away from the current syndrome-based framework in favor of more precise biological descriptors—spurred by mounting translational evidence and insights from Coronavirus Disease 2019 (COVID-19) research.
Radical rethinking is needed to address the burning issues in cancer care in low- and middle-income countries. In this Perspective, the authors outline the main challenges and top priorities for cancer research now and into the future.
Precision medicine is reshaping cancer care, but the benefits are not accessible to all patients. This Perspective outlines the major challenges to the implementation of precision oncology and discusses critical steps toward resolving these.
In this Perspective, the authors discuss the new digital communications landscape in relation to vaccines and argue that trust is key to overcoming vaccine hesitancy.
Based on their experience of setting up genomic studies in underrepresented populations, the authors propose a roadmap to enhancing inclusion and ensuring that the health benefits of genomics advances are accessible to all.
