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Glutamic acid decarboxylase is attracting much interest because of its putative involvement in two clinical disorders: stiff-man syndrome and insulin-dependent diabetes. Here we discuss the clinical significance of an autoimmune response against CAD and consider how such information may help identify the disease mechanisms of these disorders.
Reduced intake of food and enhanced physical activity, the main behavioral manifestations of self-starvation and anorexia nervosa, activate brain substrates associated with reward.