Article abstract
Nature Immunology 8, 1380 - 1389 (2007)
Published online: 11 November 2007 | doi:10.1038/ni1541
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells
Amit Awasthi1,5, Yijun Carrier2,5, Jean P S Peron3, Estelle Bettelli2, Masahito Kamanaka4, Richard A Flavell4, Vijay K Kuchroo2, Mohamed Oukka1 & Howard L Weiner2
Abstract
Regulatory T cells (Treg cells) expressing the transcription factor Foxp3 are key in maintaining the balance of immune homeostasis. However, distinct induced T regulatory type 1 (Tr1) cells that lack Foxp3 expression also regulate T cell function, mainly by producing the immunosuppressive cytokine interleukin 10 (IL-10). However, the factors required for the induction of IL-10-producing suppressive T cells are not fully understood. Here we demonstrate that dendritic cells modified by Treg cells induced the generation of IL-10-producing Tr1 cells. The differentiation of naive CD4+ T cells into IL-10-producing cells was mediated by IL-27 produced by the Treg cell–modified dendritic cells, and transforming growth factor-
amplified the generation of induced IL-10+ Tr1 cells by IL-27. Thus, IL-27 and transforming growth factor- promote the generation of IL-10-producing Tr1 cells.
- Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA.
- Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
- Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil CEP 05508-900.
- Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
- These authors contributed equally to this work.
Correspondence to: Mohamed Oukka1 e-mail: moukka@rics.bwh.harvard.edu
Correspondence to: Howard L Weiner2 e-mail: hweiner@rics.bwh.harvard.edu
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