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IL-10 or not IL-10: that is the question

Four new papers focused on how interleukin 10–producing cells are induced have led to some unexpected and intriguing observations on the nature of interleukin 17–producing T helper cells.

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Figure 1: IL-27 and IL-6, in cooperation with TGF-β, induce IL-10 production in various T helper cell subsets.

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Jankovic, D., Trinchieri, G. IL-10 or not IL-10: that is the question. Nat Immunol 8, 1281–1283 (2007). https://doi.org/10.1038/ni1207-1281

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