Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A surprising role for TLR7

Nature Immunology volume 16, pages 8–9 (2015)Cite this article

Subjects

Ligation of the Toll-like receptor TLR7 in human CD4+ T cells elicits an anergic state that may contribute to CD4+ T cell hyporesponsiveness after infection with human immunodeficiency virus type 1 and may also enhance propagation of this virus.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The engagement of TLR7 in isolated CD4+ T cells induces an anergic state and promotes HIV-1 replication.

Marina Corral Spence/Nature Publishing Group

References

  1. Dominguez-Villar, M. et al. Nat. Immunol. 16, 118–128 (2015).

    Article  CAS  Google Scholar 

  2. Baine, I., Abe, B.T. & Macian, F. Immunol. Rev. 231, 225–240 (2009).

    Article  CAS  Google Scholar 

  3. Doitsh, G. et al. Nature 505, 509–514 (2014).

    Article  CAS  Google Scholar 

  4. Lee, H.K. et al. Science 315, 1398–1401 (2007).

    Article  CAS  Google Scholar 

  5. Miyauchi, K. et al. Cell 137, 433–444 (2009).

    Article  CAS  Google Scholar 

  6. van Montfoort, N., Olagnier, D. & Hiscott, J. Cytokine Growth Factor Rev. (in the press).

  7. Douek, D.C., Roederer, M. & Koup, R.A. Annu. Rev. Med. 60, 471–484 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Michael M. Lederman is with Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA.,

    Michael M Lederman

Authors
  1. Michael M Lederman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael M Lederman.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lederman, M. A surprising role for TLR7. Nat Immunol 16, 8–9 (2015). https://doi.org/10.1038/ni.3051

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3051

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing