Regulatory T cells adopt specialized differentiation programs controlled by transcription factors. The transcription factors Blimp-1 and IRF4 are now shown to be pivotal in the maturation of effector regulatory T cells.
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References
Sakaguchi, S. et al. Cell 133, 775–787 (2008).
Koch, M.A. et al. Nat. Immunol. 10, 595–602 (2009).
Zheng, Y. et al. Nature 458, 351–356 (2009).
Cretney, E. et al. Nat. Immunol. 12, 304–311 (2011).
Nutt, S.L. et al. Nat. Rev. Immunol. 7, 923–927 (2007).
Martins, G.A. et al. Nat. Immunol. 7, 457–465 (2006).
Zheng, Y. et al. Nature 445, 936–940 (2007).
Kallies, A. et al. Nat. Immunol. 7, 466–474 (2006).
Ono, M. et al. Nature 446, 685–689 (2007).
Ouyang, W. et al. Nat. Immunol. 11, 618–627 (2010).
Pan, F. et al. Science 325, 1142–1146 (2009).
Wu, Y. et al. Cell 126, 375–387 (2006).
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Ohkura, N., Sakaguchi, S. Maturation of effector regulatory T cells. Nat Immunol 12, 283–284 (2011). https://doi.org/10.1038/ni0411-283
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DOI: https://doi.org/10.1038/ni0411-283
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