Comprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Transcriptome and protein interaction profiling in cancer cells with mutations in histone H3.3
Scientific Data Open Access 11 December 2018
-
Personalized assent for pediatric biobanks
BMC Medical Ethics Open Access 12 October 2016
-
Histone variant H3F3A promotes lung cancer cell migration through intronic regulation
Nature Communications Open Access 03 October 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schwartzentruber, J. et al. Nature 482, 226–231 (2012).
Wu, G. et al. Nat. Genet. 44, 251–253 (2012).
Behjati, S. et al. Nat. Genet. 45, 1479–1482 (2013).
Ederveen, T.H., Mandemaker, I.K. & Logie, C. Biochim. Biophys. Acta 1809, 577–586 (2011).
Elsaesser, S.J. & Allis, C.D. Cold Spring Harb. Symp. Quant. Biol. 75, 27–34 (2010).
Bjerke, L. et al. Cancer Discov. 3, 512 (2013).
Swartling, F.J. et al. Cancer Cell 21, 601–613 (2012).
Lewis, P.W. et al. Science 340, 857–861 (2013).
Bender, S. et al. Cancer Cell doi:10.1016/j.ccr.2013.10.006 (31 October 2013).
Chan, K.M. et al. Genes Dev. 27, 985–990 (2013).
Lindroth, A.M. et al. PLoS Genet. 4, e1000145 (2008).
Hon, G.C. et al. Genome Res. 22, 246–258 (2012).
Reddington, J.P. et al. Genome Biol. 14, R25 (2013).
Ward, P.S. & Thompson, C.B. Cancer Cell 21, 297–308 (2012).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Lindroth, A., Plass, C. Recurrent H3.3 alterations in childhood tumors. Nat Genet 45, 1413–1414 (2013). https://doi.org/10.1038/ng.2832
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.2832
This article is cited by
-
Transcriptome and protein interaction profiling in cancer cells with mutations in histone H3.3
Scientific Data (2018)
-
Pathologic conditions of hard tissue: role of osteoclasts in osteolytic lesion
Histochemistry and Cell Biology (2018)
-
Personalized assent for pediatric biobanks
BMC Medical Ethics (2016)
-
Histone variant H3F3A promotes lung cancer cell migration through intronic regulation
Nature Communications (2016)
-
Consent procedures in pediatric biobanks
European Journal of Human Genetics (2015)