Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Journal name:
Nature Genetics
Volume:
43,
Pages:
1224–1227
Year published:
DOI:
doi:10.1038/ng.980
Received
Accepted
Published online

Schizophrenia is a severe mental disorder affecting ~1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10−10) and 1q24.2 (rs10489202, P = 9.50 × 10−9). Our findings provide new insights into the pathogenesis of schizophrenia.

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Author information

  1. These authors contributed equally to this work.

    • Yongyong Shi,
    • Zhiqiang Li &
    • Qi Xu

Affiliations

  1. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.

    • Yongyong Shi,
    • Zhiqiang Li,
    • Ti Wang,
    • Tao Li,
    • Jiawei Shen,
    • Baojie Li,
    • Chunling Wan,
    • Shengying Qin,
    • Guang He,
    • Jue Ji,
    • Qingzhong Wang,
    • Wenjin Li,
    • Linqing Zheng,
    • Hairong Zhang &
    • Lin He
  2. Shanghai genomePilot Institutes for Genomics and Human Health, Shanghai, China.

    • Yongyong Shi,
    • Zhiqiang Li,
    • Shengying Qin,
    • Guang He &
    • Lin He
  3. Changning Mental Health Center, Shanghai, China.

    • Yongyong Shi,
    • Guoquan Zhou &
    • Weidong Ji
  4. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

    • Qi Xu
  5. Genes, Cognition and Psychosis Program, National Institute of Mental Health, the National Institutes of Health, Bethesda, Maryland, USA.

    • Fengyu Zhang &
    • Guoyin Feng
  6. Shanghai Institute of Mental Health, Shanghai, China.

    • Jianhua Chen,
    • Yifeng Xu &
    • Dengtang Liu
  7. Fourth People's Hospital, Wuhu, China.

    • Peng Wang &
    • Ping Yang
  8. Longquan Mountain Hospital of Guangxi Province, Liuzhou, China.

    • Benxiu Liu &
    • Wensheng Sun
  9. deCODE genetics, Reykjavik, Iceland.

    • Stacy Steinberg,
    • Hreinn Stefansson &
    • Kari Stefansson
  10. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.

    • Sven Cichon &
    • Markus M Nöthen
  11. Institute of Human Genetics, University of Bonn, Bonn, Germany.

    • Sven Cichon &
    • Markus M Nöthen
  12. Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain Genomic Imaging, Research Center Juelich, Juelich, Germany.

    • Sven Cichon
  13. Institute of Biological Psychiatry, Mental Health Centre Saint Hans, Copenhagen University Hospital, Roskilde, Denmark. .

    • Thomas Werge
  14. Department of Psychiatry, National University Hospital, Reykjavik, Iceland.

    • Engilbert Sigurdsson
  15. Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy.

    • Sarah Tosato
  16. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

    • Aarno Palotie
  17. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

    • Aarno Palotie
  18. Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

    • Aarno Palotie
  19. Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

    • Aarno Palotie
  20. Department of Medical Genetics, Helsinki University Central Hospital, Helsinki, Finland.

    • Aarno Palotie
  21. German Center for Neurodegenerative Disorders, Bonn, Germany.

    • Markus M Nöthen
  22. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.

    • Marcella Rietschel
  23. Department of Psychiatry, University of Bonn, Bonn, Germany.

    • Marcella Rietschel
  24. Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

    • Roel A Ophoff
  25. Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.

    • Roel A Ophoff
  26. Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.

    • Roel A Ophoff
  27. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, London, UK.

    • David A Collier
  28. Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany.

    • Dan Rujescu
  29. Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.

    • David St Clair
  30. Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

    • Lin He
  31. Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

    • Lin He

Contributions

Y.S. and L.H. conceived of and designed the study. Y.S. supervised all the experiments and data analysis. Y.S. and Z.L. conducted data analyses and drafted the manuscript. Y.S., Z.L., F.Z., D.S.C., S.S., D.R. and L.H. revised the manuscript. Y.S., G.F., Q.X., J.C., Y.X., D.L., P.W., P.Y., B. Liu, W.S., G.Z. and W.J. recruited samples. T. Wang, J.J., T.L., J.S., J.C., Q.W., W.L., L.Z., H.Z., B. Li, C.W., S.Q. and G.H. performed or contributed to the experiments. S.S., S.C., T.W., E.S., S.T., A.P., M.M.N., M.R., R.A.O., D.A.C., D.R., D.S.C., H.S. and K.S. provided the SGENE-plus data. All authors critically reviewed and approved the manuscript.

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The authors declare no competing financial interests.

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