Genetic predisposition to disease

Definition

Genetic predisposition to disease is a latent susceptibility to a disease phenotype at the genetic level. Development of the disease is not certain; it's appearance and severity is influenced by other conditions.

Latest Research and Reviews

  • Reviews |

    Dysfunction of endolysosomal pathways can lead to generalized dysfunction of the proximal tubule. Here, De Matteis and colleagues describe the role of the inositol polyphosphate 5-phosphatase, OCRL, in the endolysosomal pathway and how mutations in the encoding gene lead to the clinical manifestations of Lowe syndrome and Dent disease 2.

    • Maria Antonietta De Matteis
    • , Leopoldo Staiano
    • , Francesco Emma
    •  & Olivier Devuyst
  • Research | | open

    Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.

    • Natasha A. Karp
    • , Jeremy Mason
    • , Arthur L. Beaudet
    • , Yoav Benjamini
    • , Lynette Bower
    • , Robert E. Braun
    • , Steve D.M. Brown
    • , Elissa J. Chesler
    • , Mary E. Dickinson
    • , Ann M. Flenniken
    • , Helmut Fuchs
    • , Martin Hrabe de Angelis
    • , Xiang Gao
    • , Shiying Guo
    • , Simon Greenaway
    • , Ruth Heller
    • , Yann Herault
    • , Monica J. Justice
    • , Natalja Kurbatova
    • , Christopher J. Lelliott
    • , K.C. Kent Lloyd
    • , Ann-Marie Mallon
    • , Judith E. Mank
    • , Hiroshi Masuya
    • , Colin McKerlie
    • , Terrence F. Meehan
    • , Richard F. Mott
    • , Stephen A. Murray
    • , Helen Parkinson
    • , Ramiro Ramirez-Solis
    • , Luis Santos
    • , John R. Seavitt
    • , Damian Smedley
    • , Tania Sorg
    • , Anneliese O. Speak
    • , Karen P. Steel
    • , Karen L. Svenson
    • , International Mouse Phenotyping Consortium
    • , Yuichi Obata
    • , Tomohiro Suzuki
    • , Masaru Tamura
    • , Hideki Kaneda
    • , Tamio Furuse
    • , Kimio Kobayashi
    • , Ikuo Miura
    • , Ikuko Yamada
    • , Nobuhiko Tanaka
    • , Atsushi Yoshiki
    • , Shinya Ayabe
    • , David A. Clary
    • , Heather A. Tolentino
    • , Michael A. Schuchbauer
    • , Todd Tolentino
    • , Joseph Anthony Aprile
    • , Sheryl M. Pedroia
    • , Lois Kelsey
    • , Igor Vukobradovic
    • , Zorana Berberovic
    • , Celeste Owen
    • , Dawei Qu
    • , Ruolin Guo
    • , Susan Newbigging
    • , Lily Morikawa
    • , Napoleon Law
    • , Xueyuan Shang
    • , Patricia Feugas
    • , Yanchun Wang
    • , Mohammad Eskandarian
    • , Yingchun Zhu
    • , Lauryl M. J. Nutter
    • , Patricia Penton
    • , Valerie Laurin
    • , Shannon Clarke
    • , Qing Lan
    • , Khondoker Sohel
    • , David Miller
    • , Greg Clark
    • , Jane Hunter
    • , Jorge Cabezas
    • , Mohammed Bubshait
    • , Tracy Carroll
    • , Sandra Tondat
    • , Suzanne MacMaster
    • , Monica Pereira
    • , Marina Gertsenstein
    • , Ozge Danisment
    • , Elsa Jacob
    • , Amie Creighton
    • , Gillian Sleep
    • , James Clark
    • , Lydia Teboul
    • , Martin Fray
    • , Adam Caulder
    • , Jorik Loeffler
    • , Gemma Codner
    • , James Cleak
    • , Sara Johnson
    • , Zsombor Szoke-Kovacs
    • , Adam Radage
    • , Marina Maritati
    • , Dalila Ali-Hadji
    • , Anna Karin B. Maguire
    • , Jacqueline K. White
    • , Simon A. Maguire
    • , Brendan Doe
    • , Agnieszka Swiatkowska
    • , Wattenhofer-Donze Marie
    • , Julia Calzada-Wack
    • , Amy S. Gates
    • , Abdel Ayadi
    • , Laurent Vasseur
    • , Eckhard Wolf
    • , Dirk H Busch
    • , Jochen Graw
    • , Sabine M Hölter
    • , Charlotte Lillistone
    • , Emma J. Siragher
    • , Andreas Zimmer
    • , Oliver Eickelberg
    • , Tobias Stoeger
    • , Heather M. Wilson
    • , Johannes Beckers
    • , Susana S. Caetano
    • , Lore Becker
    • , Elizabeth J. Tuck
    • , Christopher M. Isherwood
    • , Joffrey Mianne
    • , Martin Klingenspor
    • , Cecilia Icoresi Mazzeo
    • , Yvette E. Hooks
    • , Ellen Brown
    • , Heather Cater
    • , Sylvie Jacquot
    • , Valerie E. Vancollie
    • , Valérie Gailus-Durner
    • , Caroline Sinclair
    • , Jan Rozman
    • , Lauren F. E. Anthony
    • , Claudia Stoeger
    • , Marie-Christine Birling
    • , Carsten Schmidt-Weber
    • , Selina A. Pearson
    • , David T. Lafont
    • , AliÖ Yildrim
    • , Christoph Lengger
    • , Philippe André
    • , Birgit Rathkolb
    • , Thomas Klopstock
    • , Guillaume Pavlovic
    • , Raffi Bekeredjian
    • , Irina Treise
    • , Sara Wells
    • , Christian Kipp
    • , Henrik Westerberg
    • , Evelyn Grau
    • , Ralph Steinkamp
    • , Wolfgang Wurst
    • , Fiona L. Kussy
    • , Amal El Amri
    • , Mark Sanderson
    • , Angela L. Green
    • , Manuela A. Östereicher
    • , Nicola Griggs
    • , Catherine L. Tudor
    • , Shigeharu Wakana
    • , Susan Allen
    • , Robert Brommage
    • , Monika H. Dabrowska
    • , Mark N. D. Griffiths
    • , Lillian Garrett
    • , Shay Yaacoby
    • , Navis P. S. Raj
    • , Philippe Charles
    • , Simon A. Holroyd
    • , Mike Woods
    • , Frauke Neff
    • , Elise Le Marchand
    • , Michelle Stewart
    • , Piia Keskivali-Bond
    • , Antonio Aguilar-Pimentel
    • , Stefanie Leuchtenberger
    • , David J. Gannon
    • , Wendy Gardiner
    • , Kristin Moreth
    • , Helen Kundi
    • , Susan Marschall
    • , Oana V. Amarie
    • , Markus Ollert
    • , Annemarie Zimprich
    • , Hannah Wardle-Jones
    • , Rafael Alcantara
    • , Jeanne Estabel
    • , Robbie S. B. McLaren
    • , Maksymilian T. Sumowski
    • , Carl Shannon
    • , Emma L Cambridge
    • , Antonella Galli
    • , Antje Bürger
    • , David West
    • , Laura-Anne Roberson
    • , Holger Maier
    • , David G. Melvin
    •  & Claudia Seisenberger

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