Risk loci, biological candidates and biomarkers - p257

doi:10.1038/ng0308-257

Abstract - | Full Text - Risk loci, biological candidates and biomarkers | PDF (122 KB) - Risk loci, biological candidates and biomarkers

A promoter polymorphism in the CASP8 gene is not associated with cancer risk - pp259 - 260

Christopher A Haiman, Rachel R Garcia, Laurence N Kolonel, Brian E Henderson, Anna H Wu & Loïc Le Marchand

doi:10.1038/ng0308-259

Full Text - A promoter polymorphism in the CASP8 gene is not associated with cancer risk | PDF (142 KB) - A promoter polymorphism in the CASP8 gene is not associated with cancer risk | Supplementary information

Reply to "A promoter polymorphism in the CASP8 gene is not associated with cancer risk" - pp260 - 261

Tong Sun, Yang Gao, Wen Tan, Sufang Ma, Yuankai Shi, Jiarui Yao, Yongli Guo, Ming Yang, Xuemei Zhang, Qingrun Zhang, Changqing Zeng & Dongxin Lin

doi:10.1038/ng0308-260

Full Text - Reply to "A promoter polymorphism in the CASP8 gene is not associated with cancer risk" | PDF (151 KB) - Reply to "A promoter polymorphism in the CASP8 gene is not associated with cancer risk"

Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations - pp261 - 262

Sergey Nejentsev, Thorsten Thye, Jeffrey S Szeszko, Helen Stevens, Yanina Balabanova, Amanua M Chinbuah, Martin Hibberd, Esther van de Vosse, Bachti Alisjahbana, Reinout van Crevel, Tom H M Ottenhoff, Eileen Png, Francis Drobniewski, John A Todd, Mark Seielstad & Rolf D Horstmann

doi:10.1038/ng0308-261

Full Text - Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations | PDF (150 KB) - Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations | Supplementary information

Reply to "Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations" - pp262 - 263

Chiea C Khor, Stephen J Chapman, Fredrik O Vannberg, Andrian VS Hill & Luke AJ O'Neill

doi:10.1038/ng0308-262

Full Text - Reply to "Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations" | PDF (137 KB) - Reply to "Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations"

Disentangling the roots of inherited hair disorders - pp265 - 266

Eli Sprecher

doi:10.1038/ng0308-265

Abstract - | Full Text - Disentangling the roots of inherited hair disorders | PDF (341 KB) - Disentangling the roots of inherited hair disorders

See also: Letter by Pasternack et al. | Letter by Shimomura et al.

Division of labor among meiotic genes - pp266 - 267

Luke E Berchowitz & Gregory P Copenhaver

doi:10.1038/ng0308-266

Abstract - | Full Text - Division of labor among meiotic genes | PDF (244 KB) - Division of labor among meiotic genes

See also: Article by Shinohara et al.

MicroRNAs in facial development - pp268 - 269

David E Clouthier

doi:10.1038/ng0308-268

Abstract - | Full Text - MicroRNAs in facial development | PDF (697 KB) - MicroRNAs in facial development

See also: Article by Eberhart et al.

Plant breeders go back to nature - pp269 - 270

Dani Zamir

doi:10.1038/ng0308-269

Abstract - | Full Text - Plant breeders go back to nature | PDF (476 KB) - Plant breeders go back to nature

See also: Letter by Zheng et al.

Research highlights - p273

doi:10.1038/ng0308-273

Full Text - Research highlights | PDF (88 KB) - Research highlights

What causes mitochondrial DNA deletions in human cells? - pp275 - 279

Kim J Krishnan, Amy K Reeve, David C Samuels, Patrick F Chinnery, John K Blackwood, Robert W Taylor, Sjoerd Wanrooij, Johannes N Spelbrink, Robert N Lightowlers & Doug M Turnbull

doi:10.1038/ng.f.94

Abstract - | Full Text - What causes mitochondrial DNA deletions in human cells? | PDF (644 KB) - What causes mitochondrial DNA deletions in human cells?

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer - pp281 - 283

Julius Gudmundsson, Patrick Sulem, Thorunn Rafnar, Jon T Bergthorsson, Andrei Manolescu, Daniel Gudbjartsson, Bjarni A Agnarsson, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Thorarinn Blondal, Margret Jakobsdottir, Simon N Stacey, Jelena Kostic, Kari T Kristinsson, Birgitta Birgisdottir, Shyamali Ghosh, Droplaug N Magnusdottir, Steinunn Thorlacius, Gudmar Thorleifsson, S Lilly Zheng, Jielin Sun, Bao-Li Chang, J Bradford Elmore, Joan P Breyer, Kate M McReynolds, Kevin M Bradley, Brian L Yaspan, Fredrik Wiklund, Par Stattin, Sara Lindström, Hans-Olov Adami, Shannon K McDonnell, Daniel J Schaid, Julie M Cunningham, Liang Wang, James R Cerhan, Jennifer L St Sauver, Sara D Isaacs, Kathleen E Wiley, Alan W Partin, Patrick C Walsh, Sonia Polo, Manuel Ruiz-Echarri, Sebastian Navarrete, Fernando Fuertes, Berta Saez, Javier Godino, Philip C Weijerman, Dorine W Swinkels, Katja K Aben, J Alfred Witjes, Brian K Suarez, Brian T Helfand, Michael L Frigge, Kristleifur Kristjansson, Carole Ober, Eirikur Jonsson, Gudmundur V Einarsson, Jianfeng Xu, Henrik Gronberg, Jeffrey R Smith, Stephen N Thibodeau, William B Isaacs, William J Catalona, Jose I Mayordomo, Lambertus A Kiemeney, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong & Kari Stefansson

doi:10.1038/ng.89

Abstract - | Full Text - Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer | PDF (181 KB) - Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer | Supplementary information

Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome) - pp284 - 286

David Geneviève, Valérie Proulle, Bertrand Isidor, Samuel Bellais, Valérie Serre, Fatima Djouadi, Capucine Picard, Capucine Vignon-Savoye, Brigitte Bader-Meunier, Stéphane Blanche, Marie-Christine de Vernejoul, Laurence Legeai-Mallet, Anne-Marie Fischer, Martine Le Merrer, Marie Dreyfus, Pascale Gaussem, Arnold Munnich & Valérie Cormier-Daire

doi:10.1038/ng.2007.66

Abstract - | Full Text - Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome) | PDF (300 KB) - Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome) | Supplementary information

Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations - pp287 - 289

Sheila Unger, Detlef Böhm, Frank J Kaiser, Silke Kaulfu, Wiktor Borozdin, Karin Buiting, Peter Burfeind, Johann Böhm, Francisco Barrionuevo, Alexander Craig, Kristi Borowski, Kim Keppler-Noreuil, Thomas Schmitt-Mechelke, Bernhard Steiner, Deborah Bartholdi, Johannes Lemke, Geert Mortier, Richard Sandford, Bernhard Zabel, Andrea Superti-Furga & Jürgen Kohlhase

doi:10.1038/ng.86

Abstract - | Full Text - Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations | PDF (268 KB) - Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations | Supplementary information

MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis - pp290 - 298

Johann K Eberhart, Xinjun He, Mary E Swartz, Yi-Lin Yan, Hao Song, Taylor C Boling, Allison K Kunerth, Macie B Walker, Charles B Kimmel & John H Postlethwait

doi:10.1038/ng.82

Abstract - | Full Text - MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis | PDF (882 KB) - MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis | Supplementary information

See also: News and Views by Clouthier

Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis - pp299 - 309

Miki Shinohara, Steve D Oh, Neil Hunter & Akira Shinohara

doi:10.1038/ng.83

Abstract - | Full Text - Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis | PDF (1,131 KB) - Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis | Supplementary information

See also: News and Views by Berchowitz & Copenhaver

Multiple loci identified in a genome-wide association study of prostate cancer - pp310 - 315

Gilles Thomas, Kevin B Jacobs, Meredith Yeager, Peter Kraft, Sholom Wacholder, Nick Orr, Kai Yu, Nilanjan Chatterjee, Robert Welch, Amy Hutchinson, Andrew Crenshaw, Geraldine Cancel-Tassin, Brian J Staats, Zhaoming Wang, Jesus Gonzalez-Bosquet, Jun Fang, Xiang Deng, Sonja I Berndt, Eugenia E Calle, Heather Spencer Feigelson, Michael J Thun, Carmen Rodriguez, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Edward Giovannucci, Walter C Willett, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Jr, Robert Hoover, Richard B Hayes, David J Hunter & Stephen J Chanock

doi:10.1038/ng.91

First Paragraph - | Full Text - Multiple loci identified in a genome-wide association study of prostate cancer | PDF (384 KB) - Multiple loci identified in a genome-wide association study of prostate cancer | Supplementary information

Multiple newly identified loci associated with prostate cancer susceptibility - pp316 - 321

Rosalind A Eeles, Zsofia Kote-Jarai, Graham G Giles, Ali Amin Al Olama, Michelle Guy, Sarah K Jugurnauth, Shani Mulholland, Daniel A Leongamornlert, Stephen M Edwards, Jonathan Morrison, Helen I Field, Melissa C Southey, Gianluca Severi, Jenny L Donovan, Freddie C Hamdy, David P Dearnaley, Kenneth R Muir, Charmaine Smith, Melisa Bagnato, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Beatrice N Gehr-Swain, Rosemary A Wilkinson, Angie Cox, Sarah Lewis, Paul M Brown, Sameer G Jhavar, Malgorzata Tymrakiewicz, Artitaya Lophatananon, Sarah L Bryant, The UK Genetic Prostate Cancer Study Collaborators, British Association of Urological Surgeons' Section of Oncology, The UK ProtecT Study Collaborators, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Cyril Fisher, Charles Jamieson, Colin S Cooper, Dallas R English, John L Hopper, David E Neal & Douglas F Easton

doi:10.1038/ng.90

First Paragraph - | Full Text - Multiple newly identified loci associated with prostate cancer susceptibility | PDF (299 KB) - Multiple newly identified loci associated with prostate cancer susceptibility | Supplementary information

A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures - pp322 - 328

Andrew J Sharp, Heather C Mefford, Kelly Li, Carl Baker, Cindy Skinner, Roger E Stevenson, Richard J Schroer, Francesca Novara, Manuela De Gregori, Roberto Ciccone, Adam Broomer, Iris Casuga, Yu Wang, Chunlin Xiao, Catalin Barbacioru, Giorgio Gimelli, Bernardo Dalla Bernardina, Claudia Torniero, Roberto Giorda, Regina Regan, Victoria Murday, Sahar Mansour, Marco Fichera, Lucia Castiglia, Pinella Failla, Mario Ventura, Zhaoshi Jiang, Gregory M Cooper, Samantha J L Knight, Corrado Romano, Orsetta Zuffardi, Caifu Chen, Charles E Schwartz & Evan E Eichler

doi:10.1038/ng.93

First Paragraph - | Full Text - A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures | PDF (693 KB) - A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures | Supplementary information

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth - pp329 - 334

Sandra M Pasternack, Ivar von Kügelgen, Khalid Al Aboud, Young-Ae Lee, Franz Rüschendorf, Katrin Voss, Axel M Hillmer, Gerhard J Molderings, Thomas Franz, Alfredo Ramirez, Peter Nürnberg, Markus M Nöthen & Regina C Betz

doi:10.1038/ng.84

Abstract - | Full Text - G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth | PDF (552 KB) - G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth | Supplementary information

See also: News and Views by Sprecher | Letter by Shimomura et al.

Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair - pp335 - 339

Yutaka Shimomura, Muhammad Wajid, Yoshiyuki Ishii, Lawrence Shapiro, Lynn Petukhova, Derek Gordon & Angela M Christiano

doi:10.1038/ng.100

First Paragraph - | Full Text - Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair | PDF (516 KB) - Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair | Supplementary information

See also: News and Views by Sprecher | Letter by Pasternack et al.

Natural selection has driven population differentiation in modern humans - pp340 - 345

Luis B Barreiro, Guillaume Laval, Hélène Quach, Etienne Patin & Lluís Quintana-Murci

doi:10.1038/ng.78

First Paragraph - | Full Text - Natural selection has driven population differentiation in modern humans | PDF (434 KB) - Natural selection has driven population differentiation in modern humans | Supplementary information

Regulatory changes underlying expression differences within and between Drosophila species - pp346 - 350

Patricia J Wittkopp, Belinda K Haerum & Andrew G Clark

doi:10.1038/ng.77

First Paragraph - | Full Text - Regulatory changes underlying expression differences within and between Drosophila species | PDF (316 KB) - Regulatory changes underlying expression differences within and between Drosophila species | Supplementary information

The birth and death of microRNA genes in Drosophila - pp351 - 355

Jian Lu, Yang Shen, Qingfa Wu, Supriya Kumar, Bin He, Suhua Shi, Richard W Carthew, San Ming Wang & Chung-I Wu

doi:10.1038/ng.73

First Paragraph - | Full Text - The birth and death of microRNA genes in Drosophila | PDF (265 KB) - The birth and death of microRNA genes in Drosophila | Supplementary information

Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint - pp356 - 361

Edward Owusu-Ansah, Amir Yavari, Sudip Mandal & Utpal Banerjee

doi:10.1038/ng.2007.50

First Paragraph - | Full Text - Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint | PDF (1,363 KB) - Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint | Supplementary information

Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint - pp362 - 366

Mariarosaria Musarò, Laura Ciapponi, Barbara Fasulo, Maurizio Gatti & Giovanni Cenci

doi:10.1038/ng.2007.64

First Paragraph - | Full Text - Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint | PDF (384 KB) - Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint | Supplementary information

A phenylalanine in DGAT is a key determinant of oil content and composition in maize - pp367 - 372

Peizhong Zheng, William B Allen, Keith Roesler, Mark E Williams, Shirong Zhang, Jiming Li, Kimberly Glassman, Jerry Ranch, Douglas Nubel, William Solawetz, Dinakar Bhattramakki, Victor Llaca, Stéphane Deschamps, Gan-Yuan Zhong, Mitchell C Tarczynski & Bo Shen

doi:10.1038/ng.85

First Paragraph - | Full Text - A phenylalanine in DGAT is a key determinant of oil content and composition in maize | PDF (610 KB) - A phenylalanine in DGAT is a key determinant of oil content and composition in maize | Supplementary information

See also: News and Views by Zamir

Corrigendum: Regional copy number–independent deregulation of transcription in cancer - p373

Nicolas Stransky, Céline Vallot, Fabien Reyal, Isabelle Bernard-Pierrot, Sixtina Gil Diez de Medina, Rick Segraves, Yann de Rycke, Paul Elvin, Andrew Cassidy, Carolyn Spraggon, Alexander Graham, Jennifer Southgate, Bernard Asselain, Yves Allory, Claude C Abbou, Donna G Albertson, Jean Paul Thiery, Dominique K Chopin, Daniel Pinkel & François Radvanyi

doi:10.1038/ng0308-373

Full Text - Corrigendum: Regional copy number–independent deregulation of transcription in cancer | PDF (388 KB) - Corrigendum: Regional copy number–independent deregulation of transcription in cancer