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Volume 40 Issue 4, April 2008

Cover art: Replication by Thomas Stavovy From eo art labhttp://www.eoartlab.com

Volume 40 Issue 4

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Editorial

  • Explaining research through playful analogies can enliven discussion with nonspecialists. The limits of these analogies can be used to explore the limits of explanatory scope intrinsic to scientific hypotheses.

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Obituary

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Book Review

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News & Views

  • When cytochrome c is released from mitochondria, it interacts with Apaf-1 to activate death-promoting caspases. Now, a gain-of-function mutation affecting cytochrome c with enhanced caspase-stimulatory activity is shown to have no other consequences for human health than a subclinical thrombocytopenia, showing that, in most settings, enhanced cytochrome c activity per se is not sufficient to disturb normal tissue homeostasis.

    • Eric Solary
    • Fabrizio Giordanetto
    • Guido Kroemer
    News & Views

  • Two studies report the application of high-throughput sequencing technologies to discover infectious agents associated with diseased human tissues. These findings herald a breakthrough in the field of pathogen discovery.

    • Laura MacConaill
    • Matthew Meyerson
    News & Views

  • The HIV viral lifecycle includes infection of a host cell, followed by a critical decision between latency and lysis. A new study suggests that positive feedback in the HIV-1 promoter, involving Tat protein and gene expression, has a role in this critical choice of fate.

    • Iftach Nachman
    • Sharad Ramanathan
    News & Views

  • Chromosomal position effects influence the transcription of exogenously introduced transgenes. A new study identifies molecular tools that exploit these properties to fine-tune transgenic gene expression through the use of site-specific integration and the gypsy insulator element.

    • Thomas C Tubon Jr
    • Jerry C-P Yin
    News & Views
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Brief Communication

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Article

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Letter

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Technical Report

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Corrigendum

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