Grains on the chessboard - p1261

doi:10.1038/ng1108-1261

Recent progress in mapping quantitative growth traits (QTLs) in rice yields insights into mechanisms of plant growth, hints at genomic signatures of the domestication process and promotes the prospect of agricultural improvement via introgression of beneficial variants.

Abstract - | Full Text - Grains on the chessboard | PDF (199 KB) - Grains on the chessboard

Rapidly evolving human promoter regions - pp1262 - 1263

Martin S Taylor, Tim Massingham, Yoshihide Hayashizaki, Piero Carninci, Nick Goldman & Colin A M Semple

doi:10.1038/ng1108-1262

Full Text - Rapidly evolving human promoter regions | PDF (270 KB) - Rapidly evolving human promoter regions | Supplementary information

Reply to "Rapidly evolving human promoter regions" - pp1263 - 1264

Ralph Haygood, Olivier Fedrigo & Gregory A Wray

doi:10.1038/ng1108-1263

Full Text - Reply to "Rapidly evolving human promoter regions" | PDF (137 KB) - Reply to "Rapidly evolving human promoter regions" | Supplementary information

Japonica rice carried to, not from, Southeast Asia - pp1264 - 1265

Dorian Q Fuller & Yo-Ichiro Sato

doi:10.1038/ng1108-1264

Full Text - Japonica rice carried to, not from, Southeast Asia | PDF (137 KB) - Japonica rice carried to, not from, Southeast Asia

Reply to "Japonica rice carried to, not from, Southeast Asia" - pp1265 - 1266

Takeshi Izawa, Ayahiko Shomura, Saeko Konishi, Kaworu Ebana & Masahiro Yano

doi:10.1038/ng1108-1265

Full Text - Reply to "Japonica rice carried to, not from, Southeast Asia" | PDF (120 KB) - Reply to "Japonica rice carried to, not from, Southeast Asia"

The long shadow - p1267

Jonathan Marks reviews Davenport's Dream: 21^st Century Reflections on Heredity and Eugenics by Jan A. Witkowski & John R. Inglis

doi:10.1038/ng1108-1267

Full Text - The long shadow | PDF (158 KB) - The long shadow

A glorious revolution in stem cell biology - pp1269 - 1270

Bruce A Morgan

doi:10.1038/ng1108-1269

A newly described Lgr5-expressing cell population is poised to depose the reigning monarch of the follicular hierarchy, the label-retaining cell, to claim the title as stem cell of the hair follicle.

Abstract - | Full Text - A glorious revolution in stem cell biology | PDF (204 KB) - A glorious revolution in stem cell biology

See also: Article by Jaks et al.

Combing the genome for the root cause of baldness - pp1270 - 1271

W H Irwin McLean

doi:10.1038/ng1108-1270

Two new studies report the results of genome-wide association analysis for androgenetic alopecia. The two major genetic loci identified set the scene for understanding the molecular basis of common male-pattern baldness.

Abstract - | Full Text - Combing the genome for the root cause of baldness | PDF (413 KB) - Combing the genome for the root cause of baldness

See also: Brief Communication by Hillmer et al. | Brief Communication by Richards et al.

Wilms tumor and constitutional epigenetic defects - pp1272 - 1273

Andrea Riccio

doi:10.1038/ng1108-1272

Constitutional epigenetic defects affecting the 11p15.5 imprinted region cause a number of syndromic conditions involving birth defects. Now, an analysis of a large cohort of individuals with nonsyndromic Wilms tumor demonstrates the presence of known and newly identified constitutional IGF2-H19 imprinting defects, extending the phenotype associated with soma-wide 11p15.5 imprinting disorders.

Abstract - | Full Text - Wilms tumor and constitutional epigenetic defects | PDF (134 KB) - Wilms tumor and constitutional epigenetic defects

See also: Letter by Scott et al.

Rice, rising - pp1273 - 1275

Yonghong Wang & Jiayang Li

doi:10.1038/ng1108-1273

Two new studies identify PROG1, a gene underlying a quantitative trait locus that regulates rice tiller angle and that has likely been a target for artificial selection during rice domestication. Genetic manipulation of PROG1 has the potential to promote agronomically valuable traits.

Abstract - | Full Text - Rice, rising | PDF (506 KB) - Rice, rising

See also: Letter by Tan et al. | Letter by Jin et al. | Letter by Wang et al.

Photoreceptors in evolution and disease - pp1275 - 1276

Boaz Cook & Andrew C Zelhof

doi:10.1038/ng1108-1275

A new study identifies the gene that, when mutated, causes autosomal recessive retinitis pigmentosa 25 (arRP25). The RP25 gene encodes an ortholog of Drosophila spacemaker (eyes shut), thus emphasizing common biological functions between Drosophila sensory systems and the human eye.

Abstract - | Full Text - Photoreceptors in evolution and disease | PDF (318 KB) - Photoreceptors in evolution and disease

See also: Brief Communication by Abd El-Aziz et al.

Research Highlights - p1277

doi:10.1038/ng1108-1277

Full Text - Research Highlights | PDF (111 KB) - Research Highlights

Susceptibility variants for male-pattern baldness on chromosome 20p11 - pp1279 - 1281

Axel M Hillmer, Felix F Brockschmidt, Sandra Hanneken, Sibylle Eigelshoven, Michael Steffens, Antonia Flaquer, Stefan Herms, Tim Becker, Anne-Katrin Kortüm, Dale R Nyholt, Zhen Zhen Zhao, Grant W Montgomery, Nicholas G Martin, Thomas W Mühleisen, Margrieta A Alblas, Susanne Moebus, Karl-Heinz Jöckel, Martina Bröcker-Preuss, Raimund Erbel, Roman Reinartz, Regina C Betz, Sven Cichon, Peter Propping, Max P Baur, Thomas F Wienker, Roland Kruse & Markus M Nöthen

doi:10.1038/ng.228

Axel Hillmer and colleagues present a genome-wide association study for male-pattern baldness. They confirm a previous association with the gene encoding the androgen receptor, and report replicated associations for five SNPs on chromosome 20p11.

Abstract - | Full Text - Susceptibility variants for male-pattern baldness on chromosome 20p11 | PDF (324 KB) - Susceptibility variants for male-pattern baldness on chromosome 20p11 | Supplementary information

See also: News and Views by McLean | Brief Communication by Richards et al.

Male-pattern baldness susceptibility locus at 20p11 - pp1282 - 1284

J Brent Richards, Xin Yuan, Frank Geller, Dawn Waterworth, Veronique Bataille, Daniel Glass, Kijoung Song, Gerard Waeber, Peter Vollenweider, Katja K H Aben, Lambertus A Kiemeney, Bragi Walters, Nicole Soranzo, Unnur Thorsteinsdottir, Augustine Kong, Thorunn Rafnar, Panos Deloukas, Patrick Sulem, Hreinn Stefansson, Kari Stefansson, Tim D Spector & Vincent Mooser

doi:10.1038/ng.255

Tim Spector and colleagues report a genome-wide association study for androgenic alopecia, or male-pattern baldness. They confirm a previous association with the gene encoding the androgen receptor, and identify a new association at chromosome 20p11.22, between the PAX1 and FOXA2 genes.

Abstract - | Full Text - Male-pattern baldness susceptibility locus at 20p11 | PDF (281 KB) - Male-pattern baldness susceptibility locus at 20p11 | Supplementary information

See also: News and Views by McLean | Brief Communication by Hillmer et al.

EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa - pp1285 - 1287

Mai M Abd El-Aziz, Isabel Barragan, Ciara A O'Driscoll, Leo Goodstadt, Elena Prigmore, Salud Borrego, Marcela Mena, Juan I Pieras, Mohamed F El-Ashry, Leen Abu Safieh, Amna Shah, Michael E Cheetham, Nigel P Carter, Christina Chakarova, Chris P Ponting, Shomi S Bhattacharya & Guillermo Antinolo

doi:10.1038/ng.241

Shomi Bhattacharya and colleagues report the identification of six independent mutations in an ortholog of Drosophila eys in families with autosomal recessive retinitis pigmentosa from diverse ancestral origins. A phylogenetic analysis of this gene, which spans more than 2 Mb, suggests that it has a role in the modeling of retinal architecture.

Abstract - | Full Text - EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa | PDF (360 KB) - EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa | Supplementary information

See also: News and Views by Cook & Zelhof

TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy - pp1288 - 1290

Alena íková, Viktor Stránecký, Johannes A Mayr, Markéta Tesaová, Vendula Havlíková, Jan Paul, Robert Ivánek, Andreas W Kuss, Hana Hansíková, Vilma Kaplanová, Marek Vrbacký, Hana Hartmannová, Lenka Nosková, Tomá Honzík, Zdenk Drahota, Martin Magner, Kateina Hejzlarová, Wolfgang Sperl, Jií Zeman, Josef Houtk & Stanislav Kmoch

doi:10.1038/ng.246

Stanislav Kmoch and colleagues identify mutations in TMEM70 in individuals with isolated mitochondrial ATP synthase deficiency, and demonstrate that complementation of cell lines of affected individuals with wild-type TMEM70 restores ATP synthase function.

Abstract - | Full Text - TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy | PDF (362 KB) - TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy | Supplementary information

Lgr5 marks cycling, yet long-lived, hair follicle stem cells - pp1291 - 1299

Viljar Jaks, Nick Barker, Maria Kasper, Johan H van Es, Hugo J Snippert, Hans Clevers & Rune Toftgård

doi:10.1038/ng.239

Rune Toftgård and colleagues report that Lgr5, a G protein-coupled receptor recently identified as a marker of intestinal stem cells, marks a population of hair follicle stem cells that is actively proliferating and able to give rise to all cell types in the mouse hair follicle.

Abstract - | Full Text - Lgr5 marks cycling, yet long-lived, hair follicle stem cells | PDF (1,696 KB) - Lgr5 marks cycling, yet long-lived, hair follicle stem cells | Supplementary information

See also: News and Views by Morgan

Structure and function of a transcriptional network activated by the MAPK Hog1 - pp1300 - 1306

Andrew P Capaldi, Tommy Kaplan, Ying Liu, Naomi Habib, Aviv Regev, Nir Friedman & Erin K O'Shea

doi:10.1038/ng.235

Erin O'Shea and colleagues present a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast derived from gene expression analyses in single- and multiple-mutant strains. The network reveals interactions involved in signal integration and processing and could serve as model for investigations into other gene regulatory networks.

Abstract - | Full Text - Structure and function of a transcriptional network activated by the MAPK Hog1 | PDF (912 KB) - Structure and function of a transcriptional network activated by the MAPK Hog1 | Supplementary information

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer - pp1307 - 1312

Lambertus A Kiemeney, Steinunn Thorlacius, Patrick Sulem, Frank Geller, Katja K H Aben, Simon N Stacey, Julius Gudmundsson, Margret Jakobsdottir, Jon T Bergthorsson, Asgeir Sigurdsson, Thorarinn Blondal, J Alfred Witjes, Sita H Vermeulen, Christina A Hulsbergen-van de Kaa, Dorine W Swinkels, Martine Ploeg, Erik B Cornel, Henk Vergunst, Thorgeir E Thorgeirsson, Daniel Gudbjartsson, Sigurjon A Gudjonsson, Gudmar Thorleifsson, Kari T Kristinsson, Magali Mouy, Steinunn Snorradottir, Donatella Placidi, Marcello Campagna, Cecilia Arici, Kvetoslava Koppova, Eugene Gurzau, Peter Rudnai, Eliane Kellen, Silvia Polidoro, Simonetta Guarrera, Carlotta Sacerdote, Manuel Sanchez, Berta Saez, Gabriel Valdivia, Charlotta Ryk, Petra de Verdier, Annika Lindblom, Klaus Golka, D Timothy Bishop, Margaret A Knowles, Sigfus Nikulasson, Vigdis Petursdottir, Eirikur Jonsson, Gudmundur Geirsson, Baldvin Kristjansson, Jose I Mayordomo, Gunnar Steineck, Stefano Porru, Frank Buntinx, Maurice P Zeegers, Tony Fletcher, Rajiv Kumar, Giuseppe Matullo, Paolo Vineis, Anne E Kiltie, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Thorunn Rafnar & Kari Stefansson

doi:10.1038/ng.229

Kari Stefansson and colleagues report results of a genome-wide association study for urinary bladder cancer. The strongest association was with a variant on 8q24, located 30 kb upstream of MYC in a haplotype block distinct from previously reported 8q24 cancer risk variants.

First Paragraph - | Full Text - Sequence variant on 8q24 confers susceptibility to urinary bladder cancer | PDF (341 KB) - Sequence variant on 8q24 confers susceptibility to urinary bladder cancer | Supplementary information

Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits - pp1313 - 1318

Simon N Stacey, Daniel F Gudbjartsson, Patrick Sulem, Jon T Bergthorsson, Rajiv Kumar, Gudmar Thorleifsson, Asgeir Sigurdsson, Margret Jakobsdottir, Bardur Sigurgeirsson, Kristrun R Benediktsdottir, Kristin Thorisdottir, Rafn Ragnarsson, Dominique Scherer, Peter Rudnai, Eugene Gurzau, Kvetoslava Koppova, Veronica Höiom, Rafael Botella-Estrada, Virtudes Soriano, Pablo Juberías, Matilde Grasa, Francisco J Carapeto, Pilar Tabuenca, Yolanda Gilaberte, Julius Gudmundsson, Steinunn Thorlacius, Agnar Helgason, Theodora Thorlacius, Aslaug Jonasdottir, Thorarinn Blondal, Sigurjon A Gudjonsson, Gudbjörn F Jonsson, Jona Saemundsdottir, Kristleifur Kristjansson, Gyda Bjornsdottir, Steinunn G Sveinsdottir, Magali Mouy, Frank Geller, Eduardo Nagore, José I Mayordomo, Johan Hansson, Thorunn Rafnar, Augustine Kong, Jon H Olafsson, Unnur Thorsteinsdottir & Kari Stefansson

doi:10.1038/ng.234

Simon Stacey and colleagues report results of a genome-wide association study for cutaneous basal cell carcinoma. They identify two loci, at 1p36 and 1q42, associated with BCC risk, and show that neither is associated with melanoma or pigmentation traits.

First Paragraph - | Full Text - Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits | PDF (395 KB) - Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits | Supplementary information

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility - pp1319 - 1323

Andre Franke, Tobias Balschun, Tom H Karlsen, Jurgita Sventoraityte, Susanna Nikolaus, Gabriele Mayr, Francisco S Domingues, Mario Albrecht, Michael Nothnagel, David Ellinghaus, Christian Sina, Clive M Onnie, Rinse K Weersma, Pieter C F Stokkers, Cisca Wijmenga, Maria Gazouli, David Strachan, Wendy L McArdle, Séverine Vermeire, Paul Rutgeerts, Philip Rosenstiel, Michael Krawczak, Morten H Vatn, the IBSEN study group, Christopher G Mathew & Stefan Schreiber

doi:10.1038/ng.221

Stefan Schreiber and colleagues report the results of a genome-wide association study for ulcerative colitis. Variants flanking the gene encoding the cytokine IL10 are associated with increased risk of disease, as are several other loci.

First Paragraph - | Full Text - Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility | PDF (319 KB) - Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility | Supplementary information

Variant between CPT1B and CHKB associated with susceptibility to narcolepsy - pp1324 - 1328

Taku Miyagawa, Minae Kawashima, Nao Nishida, Jun Ohashi, Ryosuke Kimura, Akihiro Fujimoto, Mihoko Shimada, Shinichi Morishita, Takashi Shigeta, Ling Lin, Seung-Chul Hong, Juliette Faraco, Yoon-Kyung Shin, Jong-Hyun Jeong, Yuji Okazaki, Shoji Tsuji, Makoto Honda, Yutaka Honda, Emmanuel Mignot & Katsushi Tokunaga

doi:10.1038/ng.231

Katsushi Tokunaga and colleagues report the results of a genome-wide association study for narcolepsy. A variant on chromosome 22 between CPT1B and CHKB is associated with increased risk of the disorder. Both gene products have previously been linked to the physiology of sleep, making each a potential susceptibility factor.

First Paragraph - | Full Text - Variant between CPT1B and CHKB associated with susceptibility to narcolepsy | PDF (416 KB) - Variant between CPT1B and CHKB associated with susceptibility to narcolepsy | Supplementary information

Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor - pp1329 - 1334

Richard H Scott, Jenny Douglas, Linda Baskcomb, Nikki Huxter, Karen Barker, Sandra Hanks, Alan Craft, Mary Gerrard, Janice A Kohler, Gill A Levitt, Sue Picton, Barry Pizer, Milind D Ronghe, Denise Williams, Factors Associated with Childhood Tumours (FACT) Collaboration, Jackie A Cook, Pascal Pujol, Eamonn R Maher, Jillian M Birch, Charles A Stiller, Kathy Pritchard-Jones & Nazneen Rahman

doi:10.1038/ng.243

Nazneen Rahman and colleagues report the identification of constitutional imprinting center mutations, epimutations and uniparental disomy in individuals with nonsyndromic Wilms tumors.

First Paragraph - | Full Text - Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor | PDF (440 KB) - Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor | Supplementary information

See also: News and Views by Riccio

Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans - pp1335 - 1340

Zubair M Ahmed, Saber Masmoudi, Ersan Kalay, Inna A Belyantseva, Mohamed Ali Mosrati, Rob W J Collin, Saima Riazuddin, Mounira Hmani-Aifa, Hanka Venselaar, Mayya N Kawar, Abdelaziz Tlili, Bert van der Zwaag, Shahid Y Khan, Leila Ayadi, S Amer Riazuddin, Robert J Morell, Andrew J Griffith, Ilhem Charfedine, Refik Çaylan, Jaap Oostrik, Ahmet Karaguzel, Abdelmonem Ghorbel, Sheikh Riazuddin, Thomas B Friedman, Hammadi Ayadi & Hannie Kremer

doi:10.1038/ng.245

Hannie Kremer and colleagues report the identification of mutations in LROMT associated with profound nonsyndromic hearing loss. LRTOMT has two alternative reading frames and encodes two different proteins, LRTOMT1 and LRTOMT2.

First Paragraph - | Full Text - Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans | PDF (725 KB) - Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans | Supplementary information

Disruption of an AP-2 binding site in an IRF6 enhancer is associated with cleft lip - pp1341 - 1347

Fedik Rahimov, Mary L Marazita, Axel Visel, Margaret E Cooper, Michael J Hitchler, Michele Rubini, Frederick E Domann, Manika Govil, Kaare Christensen, Camille Bille, Mads Melbye, Astanand Jugessur, Rolv T Lie, Allen J Wilcox, David R Fitzpatrick, Eric D Green, NISC Comparative Sequencing Program, Peter A Mossey, Julian Little, Regine P Steegers-Theunissen, Len A Pennacchio, Brian C Schutte & Jeffrey C Murray

doi:10.1038/ng.242

Nonsyndromic cleft lip with or without cleft palate has been associated with SNPs in the IRF6 gene. Now Jeff Murray and colleagues report the identification of a common variant in a previously unknown IRF6 enhancer that shows strong evidence of association with cleft lip only and disrupts the binding site of transcription factor AP-2.

First Paragraph - | Full Text - Disruption of an AP-2 binding site in an IRF6 enhancer is associated with cleft lip | PDF (647 KB) - Disruption of an AP-2 binding site in an IRF6 enhancer is associated with cleft lip | Supplementary information

Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein - pp1348 - 1353

Yongsu Jeong, Federico Coluccio Leskow, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Anastasia Yocum, Christele Dubourg, Xue Li, Xin Geng, Guillermo Oliver & Douglas J Epstein

doi:10.1038/ng.230

Doug Epstein and colleagues present biochemical and transgenic studies implicating Six3 in the regulation of Shh forebrain expression through direct binding to a remote enhancer. The work was driven by the discovery of a rare variant in this enhancer in an individual with holoprosencephaly

First Paragraph - | Full Text - Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein | PDF (610 KB) - Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein | Supplementary information

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity - pp1354 - 1359

Alexandra Chadt, Katja Leicht, Atul Deshmukh, Lake Q Jiang, Stephan Scherneck, Ulrike Bernhardt, Tanja Dreja, Heike Vogel, Katja Schmolz, Reinhart Kluge, Juleen R Zierath, Claus Hultschig, Rob C Hoeben, Annette Schürmann, Hans-Georg Joost & Hadi Al-Hasani

doi:10.1038/ng.244

Hadi Al-Hasani and colleagues report that a frameshift deletion in Tbc1d1 in lean SJL mice underlies a quantitative trait locus conferring protection against high-fat diet-induced obesity. TBC1D1 seems to influence metabolism by regulating fatty acid uptake and oxidation in skeletal muscle cells.

First Paragraph - | Full Text - Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity | PDF (569 KB) - Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity | Supplementary information

Control of a key transition from prostrate to erect growth in rice domestication - pp1360 - 1364

Lubin Tan, Xianran Li, Fengxia Liu, Xianyou Sun, Chenggang Li, Zuofeng Zhu, Yongcai Fu, Hongwei Cai, Xiangkun Wang, Daoxin Xie & Chuanqing Sun

doi:10.1038/ng.197

Chuanqing Sun and colleagues show that the gene PROG1, encoding a zinc-finger protein, determines the erect growth habit in rice. Sequencing of 182 varieties of cultivated rice reveals an identical mutation in the PROG1 coding region, suggesting a common origin for erect growth during rice domestication.

First Paragraph - | Full Text - Control of a key transition from prostrate to erect growth in rice domestication | PDF (758 KB) - Control of a key transition from prostrate to erect growth in rice domestication | Supplementary information

See also: News and Views by Wang & Li | Letter by Jin et al. | Letter by Wang et al.

Genetic control of rice plant architecture under domestication - pp1365 - 1369

Jian Jin, Wei Huang, Ji-Ping Gao, Jun Yang, Min Shi, Mei-Zhen Zhu, Da Luo & Hong-Xuan Lin

doi:10.1038/ng.247

Hong-Xuan Lin and colleagues report that the gene PROG1 has an important role in determining the architecture of wild rice, including tiller angle and number of tillers. PROG1 encodes a zinc-finger transcription factor, and the authors suggest that selection of an amino acid substitution in PROG1 during domestication facilitated the transition to the architecture of domesticated rice.

First Paragraph - | Full Text - Genetic control of rice plant architecture under domestication | PDF (614 KB) - Genetic control of rice plant architecture under domestication | Supplementary information

See also: News and Views by Wang & Li | Letter by Tan et al. | Letter by Wang et al.

Control of rice grain-filling and yield by a gene with a potential signature of domestication - pp1370 - 1374

Ertao Wang, Jianjun Wang, Xudong Zhu, Wei Hao, Linyou Wang, Qun Li, Lixia Zhang, Wei He, Baorong Lu, Hongxuan Lin, Hong Ma, Guiquan Zhang & Zuhua He

doi:10.1038/ng.220

Zuhua He and colleagues identify the gene underlying a quantitative trait locus for grain-filling in rice, which contributes to grain weight. The gene, GIF1, encodes a protein with cell-wall invertase activity and may have been under selection during rice domestication.

First Paragraph - | Full Text - Control of rice grain-filling and yield by a gene with a potential signature of domestication | PDF (597 KB) - Control of rice grain-filling and yield by a gene with a potential signature of domestication | Supplementary information

See also: News and Views by Wang & Li | Letter by Tan et al. | Letter by Jin et al.

Single-copy insertion of transgenes in Caenorhabditis elegans - pp1375 - 1383

Christian Frøkjær-Jensen, M Wayne Davis, Christopher E Hopkins, Blake J Newman, Jason M Thummel, Søren-Peter Olesen, Morten Grunnet & Erik M Jorgensen

doi:10.1038/ng.248

Erik Jorgensen and colleagues report a highly efficient method for generating single-copy transgene insertions in C. elegans. Notably, these single-copy transgenes are expressed at endogenous levels and can be expressed in the female and male germlines.

Abstract - | Full Text - Single-copy insertion of transgenes in Caenorhabditis elegans | PDF (714 KB) - Single-copy insertion of transgenes in Caenorhabditis elegans | Supplementary information

Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans - p1384

Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noël P Burtt, Mark J Rieder, Gregory M Cooper, Charlotta Roos, Benjamin F Voight, Aki S Havulinna, Björn Wahlstrand, Thomas Hedner, Dolores Corella, E Shyong Tai, Jose M Ordovas, Göran Berglund, Erkki Vartiainen, Pekka Jousilahti, Bo Hedblad, Marja-Riitta Taskinen, Christopher Newton-Cheh, Veikko Salomaa, Leena Peltonen, Leif Groop, David M Altshuler & Marju Orho-Melander

doi:10.1038/ng1108-1384a

Full Text - Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | PDF (82 KB) - Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Corrigendum: Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum - p1384

Juliane Najm, Denise Horn, Isabella Wimplinger, Jeffrey A Golden, Victor V Chizhikov, Jyotsna Sudi, Susan L Christian, Reinhard Ullmann, Alma Kuechler, Carola A Haas, Armin Flubacher, Lawrence R Charnas, Gökhan Uyanik, Ulrich Frank, Eva Klopocki, William B Dobyns & Kerstin Kutsche

doi:10.1038/ng1108-1384b

Full Text - Corrigendum: Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum | PDF (82 KB) - Corrigendum: Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum