Letter abstract
Nature Genetics 40, 1307 - 1312 (2008)
Published online: 14 September 2008 | doi:10.1038/ng.229
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Lambertus A Kiemeney1,2,3,38, Steinunn Thorlacius4,38, Patrick Sulem4, Frank Geller4, Katja K H Aben1,3, Simon N Stacey4, Julius Gudmundsson4, Margret Jakobsdottir4, Jon T Bergthorsson4, Asgeir Sigurdsson4, Thorarinn Blondal4, J Alfred Witjes2, Sita H Vermeulen1, Christina A Hulsbergen-van de Kaa5, Dorine W Swinkels6, Martine Ploeg2, Erik B Cornel7, Henk Vergunst8, Thorgeir E Thorgeirsson4, Daniel Gudbjartsson4, Sigurjon A Gudjonsson4, Gudmar Thorleifsson4, Kari T Kristinsson4, Magali Mouy4, Steinunn Snorradottir4, Donatella Placidi9, Marcello Campagna9, Cecilia Arici9, Kvetoslava Koppova10, Eugene Gurzau11, Peter Rudnai12, Eliane Kellen13,14, Silvia Polidoro15,16, Simonetta Guarrera15,16, Carlotta Sacerdote17, Manuel Sanchez18, Berta Saez19, Gabriel Valdivia20, Charlotta Ryk21, Petra de Verdier21, Annika Lindblom21, Klaus Golka22, D Timothy Bishop23, Margaret A Knowles24, Sigfus Nikulasson25, Vigdis Petursdottir25, Eirikur Jonsson26, Gudmundur Geirsson26, Baldvin Kristjansson26, Jose I Mayordomo27,28, Gunnar Steineck29,30, Stefano Porru9, Frank Buntinx13,31, Maurice P Zeegers32,33, Tony Fletcher34, Rajiv Kumar35, Giuseppe Matullo15,16, Paolo Vineis15,36, Anne E Kiltie24, Jeffrey R Gulcher4, Unnur Thorsteinsdottir4,37, Augustine Kong4, Thorunn Rafnar4 & Kari Stefansson4,37
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 
10-12). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 10-7).
- Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
- Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
- Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands.
- deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
- Department of Pathology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
- Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
- Department of Urology, Streekziekenhuis Midden-Twente, 7550 AM Hengelo, The Netherlands.
- Department of Urology, Canisius Wilhelmina Ziekenhuis, 6500 GS Nijmegen, The Netherlands.
- Department of Experimental and Applied Medicine - Section of Occupational Medicine and Industrial Hygiene, University of Brescia, 25125 Brescia, Italy.
- State Health Institute, SK-975 56 Banska Bystrica, Slovakia.
- Environmental Health Center, 400166 Cluj Napoca, Romania.
- National Institute of Environmental Health, H-1450 Budapest, Hungary.
- Department of General Practice, Catholic University of Leuven, 3000 Leuven, Belgium.
- Leuven University Centre for Cancer Prevention (LUCK), 3000 Leuven, Belgium.
- ISI Foundation (Institute for Scientific Interchange), Turin, Italy.
- Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Turin, Italy.
- Unit of Cancer Epidemiology, University of Turin and Centre for Cancer Epidemiology and Prevention (CPO Piemonte), 10123 Turin, Italy.
- Division of Urology, University Hospital, 50009 Zaragoza, Spain.
- Health Science Institute, 50009 Zaragoza, Spain.
- Department of Urology, University of Zaragoza School of Medicine, 50009 Zaragoza, Spain.
- Dept. Molecular Medicine and Surgery, Karolinska Institutet, S171 76 Stockholm, Sweden.
- Institute for Occupational Physiology at the University of Dortmund, Dortmund, Germany.
- Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St. James's University Hospital, LS9 7TF Leeds, UK.
- Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St. James's University Hospital, LS9 7TF Leeds, UK.
- Department of Pathology, Landspitali-University Hospital, 101 Reykjavik, Iceland.
- Department of Urology, Landspitali-University Hospital, 101 Reykjavik, Iceland.
- Division of Medical Oncology, University Hospital, 50009 Zaragoza, Spain.
- Nanotechnology Institute of Aragon, Health Science Institute, 50009 Zaragoza, Spain.
- Department of Oncology and Pathology, Karolinska Hospital, S171 76 Stockholm, Sweden.
- Department of Oncology, Sahlgrenska University Hospital, S-413 45 Goteborg, Sweden.
- Department of General Practice, Maastricht University, 6200 MD Maastricht, The Netherlands.
- Unit of Genetic Epidemiology, Department of Public Health and Epidemiology, University of Birmingham, B15 2TT Birmingham, UK.
- Department of Complex Genetics, Cluster of Genetics and Cell Biology, Nutrition and Toxicology Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands.
- London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK.
- Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg D-69120, Germany.
- Department of Epidemiology and Public Health, Imperial College, W2 1PG London, UK.
- Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
- These authors contributed equally to this work.
Correspondence to: Lambertus A Kiemeney1,2,3,38 e-mail: b.kiemeney@ebh.umcn.nl
Correspondence to: Kari Stefansson4,37 e-mail: kstefans@decode.is
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood?brain barrier disruptionJournal of Cerebral Blood Flow & Metabolism Brief Communication
BRAF Mutations Are Common Somatic Events in Melanocytic Nevi 1Journal of Investigative Dermatology Original Article
Sequence variants at the TERT-CLPTM1L locus associate with many cancer typesNature Genetics Letter (01 Feb 2009)
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populationsNature Genetics Letter (01 Apr 2009)
See all 51 matches for Research
