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Association between genetic variations at 8q24 and prostate cancer risk in Mexican Men

Prostate Cancer and Prostatic Diseases volume 25, pages 507–512 (2022)Cite this article

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Abstract

Background

Variants of 8q24 locus have been associated with prostate cancer (PCa) susceptibility. This study aims to analyze the genetic basis of PCa susceptibility in Mexican men by analyzing SNPs in the 8q24 locus for the first time.

Methods

A case-control study was performed in 875 men recruited from the Mexican Social Security Institute, 326 patients with PCa, and 549 non-PCa patients (88 with benign prostatic hyperplasia BPH and 461 healthy controls). The 8q24 locus SNPs: rs16901979, rs16983267, rs1447295, and rs7837328 were genotyped by allelic discrimination assays using TaqMan probes. Statistical analysis was performed using Epi Info statistical 7.0 and SNPstats softwares.

Results

All genotype frequencies were in Hardy-Weinberg Equilibrium. No differences were observed in genotype distribution between PCa and non-PCa patients for rs6983267. Under different inheritance models, the rs16901979, rs1447295, and rs7837328 SNPs were associated with PCa (OR = 2.8, 1.8, and 1.72, respectively; Pc < 0.001) when comparing PCa patients against controls. This association remains between PCa and BPH patients under different models (OR = 8.5, 2.2, and 1.9, respectively; Pc < 0.001). There were no significant differences in allele and genotype distribution among BPH patients and controls. The combined effect of the alleles CGAA for the SNPs rs16901979, rs6983267, rs1447295, and rs7837328 showed significant differences between PCa patients and controls (OR = 2.9, 95% CI = 1.48–5.83, Pc = 0.008). Four 8q24 variants were not associated with D’Amico score, age at diagnosis, and bone metastases.

Conclusions

Our study provides the first confirmation that variants rs16901979, rs1447295, and 7837328 at 8q24 locus are associated with PCa susceptibility in Mexican men.

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Acknowledgements

The authors thank the patients for their selfless participation.

Author contributions

SRB: devised the project, funding acquisition, formal analysis, writing. MGEJ, FVOS, CPMB, IPDI: resources, investigation. ATAR: validation, PUK: writing - original draft preparation. GELA: writing - original draft preparation, BLM: reviewing and Editing.

Funding

This work was supported by IMSS grant no. FIS/IMSS/PROT/G15/1416.

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Authors and Affiliations

  1. Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social (IMSS), Monterrey, Nuevo León, Mexico

    B. Silva-Ramirez, E. J. Macías-González, K. Peñuelas-Urquides, L. A. González-Escalante & M. Bermúdez de León

  2. Becario de la Dirección General de Calidad y Educación en Salud (DGCES), Secretaria de Salud, Monterrey, Nuevo León, Mexico

    E. J. Macías-González

  3. UMAE-Hospital de Especialidades No. 25, Instituto Mexicano del Seguro Social (IMSS), Monterrey, Nuevo León, Mexico

    O. S. Frausto-Valdes, M. B. Calao-Pérez, D. I. Ibarra-Pérez, J. E. Torres-García & A. R. Aragón-Tovar

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Correspondence to B. Silva-Ramirez.

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Silva-Ramirez, B., Macías-González, E.J., Frausto-Valdes, O.S. et al. Association between genetic variations at 8q24 and prostate cancer risk in Mexican Men. Prostate Cancer Prostatic Dis 25, 507–512 (2022). https://doi.org/10.1038/s41391-021-00461-x

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