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A new study shows that 'anticipation' occurs in the autosomal dominant form of dyskeratosis congenita and is due to inheritance of short telomeres and mutations in TERC (encoding telomerase RNA).
Specific post-translational histone modifications correlate with distinct patterns of gene activity. A new study of the mouse Dntt promoter shows that changes in gene activity are associated with local changes in histone modification that then spread outward in both directions, locking in the altered pattern of transcription.
Philadelphia chromosome–positive leukemia may present as chronic myeloid leukemia or B-cell acute lymphoblastic leukemia. A new study shows that certain Src kinases are necessary for the induction of B-cell acute lymphoblastic leukemia but not chronic myeloid leukemia.
The rat genome sequence, the third mammalian genome sequence to be generated, was recently reported in Nature. The sequence provides new insights into mammalian genome evolution and the opportunity to translate decades of descriptive phenotyping to an understanding of the molecular mechanisms that underlie these phenotypes.
