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Published online 20 July 2007 | Nature | doi:10.1038/news070716-16

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Manic mood swings can destroy grey matter

Bipolar episodes decrease brain size, and possibly intelligence.

Grey matter in the brains of people with bipolar disorder is destroyed with each manic or depressive episode.

This was the finding of an MRI study of 21 patients with bipolar disorder, a mental illness marked by successive episodes of mania followed by deep depression.

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