Effectiveness of EGFR treatment is impaired through an early adaptive response. TNF–JNK–Axl–ERK signaling contributes to this primary resistance to EGFR inhibition and might serve as novel target to improve EGFR inhibition.
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Warta, R., Herold-Mende, C. Helping EGFR inhibition to block cancer. Nat Neurosci 20, 1035–1037 (2017). https://doi.org/10.1038/nn.4605
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DOI: https://doi.org/10.1038/nn.4605