Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Imagine a journey through time and space

The hippocampus, a structure critical for memory and navigation, contains both place and episodic cell assemblies. Synchronous input from the medial septum is crucial for inducing spatial and temporal neural sequences. These sequences are, in turn, necessary for constructing episodic cells and, in the absence of sensory input, place cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Illustration of episodic sequences before and during medial septal inactivation.

References

  1. Buzsáki, G. & Moser, E.I. Nat. Neurosci. 16, 130–138 (2013).

    Article  Google Scholar 

  2. Pastalkova, E., Itskov, V., Amarasingham, A. & Buzsaki, G. Science 321, 1322–1327 (2008).

    Article  CAS  Google Scholar 

  3. Wang, Y., Romani, S., Lustig, B., Leonardo, A. & Pastalkova, E. Nat. Neurosci. 18, 282–288 (2015).

    Article  CAS  Google Scholar 

  4. Stewart, M. & Fox, S.E. Trends Neurosci. 13, 163–168 (1990).

    Article  CAS  Google Scholar 

  5. Petsche, H., Stumpf, C. & Gogolak, G. Electroencephalogr. Clin. Neurophysiol. 14, 202–211 (1962).

    Article  CAS  Google Scholar 

  6. Green, J.D. & Arduini, A.A. J. Neurophysiol. 17, 533–557 (1954).

    Article  CAS  Google Scholar 

  7. MacDonald, C.J., Lepage, K.Q., Eden, U.T. & Eichenbaum, H. Neuron 71, 737–749 (2011).

    Article  CAS  Google Scholar 

  8. Hasselmo, M.E. Hippocampus 15, 936–949 (2005).

    Article  Google Scholar 

  9. Fyhn, M., Molden, S., Witter, M.P., Moser, E.I. & Moser, M.B. Science 305, 1258–1264 (2004).

    Article  CAS  Google Scholar 

  10. Hafting, T., Fyhn, M., Molden, S., Moser, M.B. & Moser, E.I. Nature 436, 801–806 (2005).

    Article  CAS  Google Scholar 

  11. Brandon, M.P., Koenig, J., Leutgeb, J.K. & Leutgeb, S. Neuron 82, 789–796 (2014).

    Article  CAS  Google Scholar 

  12. Koenig, J., Linder, A.N., Leutgeb, J.K. & Leutgeb, S. Science 332, 592–595 (2011).

    Article  CAS  Google Scholar 

  13. Wilson, M.A. & McNaughton, B.L. Science 265, 676–679 (1994).

    Article  CAS  Google Scholar 

  14. Pavlides, C. & Winson, J. J. Neurosci. 9, 2907–2918 (1989).

    Article  CAS  Google Scholar 

  15. Kudrimoti, H.S., Barnes, C.A. & McNaughton, B.L. J. Neurosci. 19, 4090–4101 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lisa M Giocomo.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Giocomo, L. Imagine a journey through time and space. Nat Neurosci 18, 163–164 (2015). https://doi.org/10.1038/nn.3926

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3926

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing