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The authors optogenetically suppressed CA1 pyramidal neurons during awake sharp-wave ripples (SPW-R) as mice were learning reward locations in a multiwell maze. Comparison of place cells’ activities before and after SPW-R manipulation suggests that interference with SPW-R-associated activity during learning prevents stabilization and refinement of the hippocampal map.
Cells in the hippocampal–entorhinal circuit, which fire in response to navigational variables such as location or speed, are shown also to encode continuous, task-relevant but non-spatial variables such as sound frequency.
Many spatial correlates have been identified that form the neural basis for navigation. Two studies have now uncovered a new cell type: bidirectional cells, which fire when the head is pointing in one of two opposing directions.