Cued memory reactivation during sleep influences skill learning

Journal name:
Nature Neuroscience
Volume:
15,
Pages:
1114–1116
Year published:
DOI:
doi:10.1038/nn.3152
Received
Accepted
Published online

Abstract

Information acquired during waking can be reactivated during sleep, promoting memory stabilization. After people learned to produce two melodies in time with moving visual symbols, we enhanced relative performance by presenting one melody during an afternoon nap. Electrophysiological signs of memory processing during sleep corroborated the notion that appropriate auditory stimulation that does not disrupt sleep can nevertheless bias memory consolidation in relevant brain circuitry.

At a glance

Figures

  1. Methods and behavioral results.
    Figure 1: Methods and behavioral results.

    (a) Subjects learned to play melodies with four fingers of the left hand while watching circles that indicated which key to press when. Circles ascended at 10.8 cm s−1 toward four stationary targets (dashed yellow outlines). After initial learning trials, the amount of advance information was reduced using an opaque mask (shown here as transparent). Two melodies were repeatedly practiced (red and blue). Baseline melodies (green) were played during testing periods before and after the nap. Either the high melody (eight subjects) or the low melody (eight subjects) was presented covertly (cued) during sleep. (b) Accuracy scores (percent correct responses) were computed according to whether the correct key was pressed at the proper time. Differences were analyzed using two-tailed paired t tests (n = 16; *P < 0.05, **P < 0.005). Error bars represent s.e.m. in each condition after removing across-subject variability (that is, subtracting the mean across all conditions for each individual), which provides variability estimates consistent with the error terms used in the critical within-subject comparisons.

  2. Sleep cues and physiology.
    Figure 2: Sleep cues and physiology.

    (a, b) Reactivation advantage was correlated with the percentage of time in SWS (n = 14, Pearson correlation, r = 0.60, P = 0.02) and with the number of sleep spindles during SWS at the F4 location (r = 0.74, P = 0.002). (c) Spindle correlation values, shown with a color scale on a topographic map of the head viewed from above, were largest over cortical regions contralateral to the hand used to perform the melodies.

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Author information

Affiliations

  1. Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois, USA.

    • James W Antony,
    • Eric W Gobel,
    • Paul J Reber &
    • Ken A Paller
  2. Department of Psychology, Northwestern University, Evanston, Illinois, USA.

    • Justin K O'Hare,
    • Paul J Reber &
    • Ken A Paller

Contributions

J.W.A. and K.A.P. conceived the design and all of the authors contributed to developing the procedures. J.W.A. and J.K.O. collected the data. J.W.A. analyzed the data. J.W.A. and K.A.P. wrote the manuscript. All of the authors discussed the results and finalized the manuscript.

Competing financial interests

The authors declare no competing financial interests.

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Supplementary information

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  1. Supplementary Text and Figures (1.2M)

    Supplementary Figures 1–5, Supplementary Table 1 and Supplementary Results

Movies

  1. Supplementary Movie 1 (10.6M)

    A real-time movie of task performance.

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