Metastasis: a therapeutic target for cancer
Patricia S Steeg* and Dan Theodorescu*
Correspondence *Laboratory of Molecular Pharmacology, National Cancer Institute, Room 1122, Building 37, 37 Convent Drive, Bethesda, MD 20892, USA
Email steegp@mail.nih.gov
Correspondence *University of Virginia, Room 2561, 2nd Floor, West Clinics, Hospital Drive, Charlottesville, VA 22908–0422, USA
Email theodorescu@virginia.edu
Metastasis remains the major driver of mortality in patients with cancer. The similarities and differences between primary tumors and metastases are described, and pathways controlling the colonization of a distant organ and incorporation of anti-metastatic therapies into clinical testing are discussed. The authors emphasize that the time is ripe for metastasis and metastatic colonization to enter mainstream clinical development and testing.
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