Browse Articles

Toxoplasma gondii acquires host cytosolic materials, yet the mechanism remains unknown. Wan et al. reveal the micropore as an essential organelle at the plasma membrane for endocytosis of host cytosolic proteins and biotin, and Golgi ceramide.

Lifetime-encoded materials are attractive as optical markers. Here, the authors report a design strategy for true orthogonality in encoding based on heterometallic rare-earth MOFs with independently variable lifetime and composition.

The opportunity for sexual selection is a key evolutionary parameter but we know little about its temporal dynamics. Using data from multiple animal species the authors show that this metric varies rapidly through time and that simulations should be used to avoid substantial misinterpretation.

Integrating green hydrogen production with the generation of valuable chemicals has the potential to increase the competitiveness of the system. Here, the authors quantitatively evaluate the energetic benefit of coupling hydrogen production with the hydrogenation of feedstocks in a photoelectrochemical device.

Corrosion is a ubiquitous failure mode in materials. Here the authors report a percolating 1D wormhole corrosion morphology using advanced electron microscopy and theoretical simulations. The work presents a vacancy mapping method with nm-resolution, identifying the incubation sites of the wormholes.

The study of the pathophysiology and possible interventions for non-ST-segment elevation myocardial infarction is hindered by the lack of a reproducible pre-clinical model. Here, authors develop an ovine model to reproduce post-ischemic remodeling in non-ST myocardial infarction and reveal distinct complex sugar moieties in cellular membranes and extracellular matrix patterns in infarcted tissue.

Lymphatic malformation (LM) is a rare, non-malignant vascular abnormality that can progress to lymphangiosarcoma (LAS). The authors use genetic mouse models to show that autophagy inhibition blocks the progression of LM to LAS by decreasing osteopontin expression and Jak/Stat signalling.

Bacteriophage therapy is evolving as a promising approach to tackling bacterial infection, even in the case of emerging antibiotic resistance. In this work, authors present the topical application of numerous Cutibacterium acnes phage in an in vivo mouse model of acne vulgaris.

If and how non-bonding ligands mediate the electronic states of metal sites is interesting yet remains to be explored. Here the authors show that a non-covalent phenanthroline can promote the population of Co⁴⁺ and induce polaron-like Co sites for improved water oxidation.

HIV infection results in the depletion of CD4⁺ T cells overtime and the loss of coordinated cellular immunity, but how this corresponds to the SIV infected African Green Monkey (AGM) model of non-progressive disease is not known. Here the authors assess the impact of experimental CD4⁺ T cell depletion in AGM and show that lack of disease progression and resistance to AIDS in this model are independent of CD4⁺ T cell loss.

The authors present an intelligent metasurface system that uses a target detection algorithm combined with a depth camera, to automatically detect the position of moving targets and achieve real-time wireless communications. The system can operate for multiple targets in limited ambient light, outdoor and other realistic environments.

The basal ganglia process sensory and motor related information, but it is not known how movement affects sensory integration. Here, the authors show using in vivo whole-cell recordings that striatal neurons respond to both sensory stimuli and spontaneous whisking and that sensory responses are attenuated by whisking.

The functional changes of individual clones in single cell RNA sequencing (scRNA-seq) data remain elusive. Here, the authors develop PhylEx that integrates bulk genomics data with co-occurrences of mutations revealed by scRNA-seq data and apply it to high-grade serous ovarian cancer cell line and breast cancer datasets.

Marine fishes can substantially contribute to the inorganic carbon cycle through the excretion of intestinally precipitated carbonates, but the underlying drivers remain largely unknown. This study identifies the environmental factors and fish traits that predict carbonate excretion rate and mineralogical composition in tropical reef fishes.

Two-dimensional materials are promising platforms for the realization of an excitonic insulator state. Here the authors report evidence for an excitonic insulator in a single-layer ZrTe2 based on ARPES measurements.

The integrated CO₂ capture and conversion (iCCC) technology has been booming for carbon neutrality. Here the authors optimized the Ni–CaO composite catalyst to promote iCCC involving consecutive high-temperature Calcium-looping and dry reforming of methane and illustrated their synergistic promotions at the suitable catalyst interface.

The NHS COVID-19 digital contact tracing app was designed to notify people of potential exposure to SARS-CoV-2. Here, the authors summarise the uptake and engagement with the app in its first year, and estimate its epidemiological impact in terms of numbers of cases, hospitalisations, and deaths averted.

Women of reproductive age may have specific concerns relating to perceived impacts on fertility and menstrual cycles that make them hesitant to receive COVID-19 vaccination. In this study, the authors explore COVID-19 vaccine uptake rates in women of reproductive age using linked data for ~13 million women in England.

The antigen-B-cell-receptor interaction is the driving force of terminal B cell development that spans from B cell activation to antibody secreting plasma cells. Here authors determine, using DNA-PAINT super-resolution microscopy, how antigen affinity and valency define antigen binding to BCR in an in vitro system allowing precision control of these parameters.

The full potential of single-cell RNA-sequencing applied to precision medicine has yet to be reached. Here, we propose a drug recommendation system ASGARD, which predicts drugs by considering cell clusters to address the intercellular heterogeneity within each patient.