Browse Articles

  • Article | | open

    BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.

    • Jinping Liu
    • , Alex Kruswick
    • , Hien Dang
    • , Andy D. Tran
    • , So Mee Kwon
    • , Xin Wei Wang
    •  & Philipp Oberdoerffer
  • Article | | open

    Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.

    • Iwo Kucinski
    • , Michael Dinan
    • , Golnar Kolahgar
    •  & Eugenia Piddini
  • Article | | open

    The interface of layered cathodes for sodium ion batteries is subject to atmospheric and electrochemical corrosions. Here, the authors demonstrate an environmentally stable interface via titanium enriched surface reconstruction in a layered manganese-based oxide.

    • Shaohua Guo
    • , Qi Li
    • , Pan Liu
    • , Mingwei Chen
    •  & Haoshen Zhou
  • Article | | open

    Current national pledges to reduce greenhouse gas emissions track to a temperature rise of about 3 °C. Here the authors use future projections to show that 3 °C warming under a business as usual scenario would result in large increases in ozone concentrations, off-setting any benefits from mitigation policies.

    • A. Fortems-Cheiney
    • , G. Foret
    • , G. Siour
    • , R. Vautard
    • , S. Szopa
    • , G. Dufour
    • , A. Colette
    • , G. Lacressonniere
    •  & M. Beekmann
  • Article | | open

    The lack of models that mimic hepatitis B virus (HBV) infection in a physiologically relevant context has hampered drug development. Here, Winer et al. establish a self-assembling, primary hepatocyte co-culture system that can be infected with patient-derived HBV without further modifications.

    • Benjamin Y. Winer
    • , Tiffany S. Huang
    • , Eitan Pludwinski
    • , Brigitte Heller
    • , Felix Wojcik
    • , Gabriel E. Lipkowitz
    • , Amit Parekh
    • , Cheul Cho
    • , Anil Shrirao
    • , Tom W. Muir
    • , Eric Novik
    •  & Alexander Ploss
  • Article | | open

    Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4 signaling in mice modulates this switch in the niche.

    • Xuan Jiang
    • , John S. Hawkins
    • , Jerry Lee
    • , Carlos O. Lizama
    • , Frank L. Bos
    • , Joan P. Zape
    • , Prajakta Ghatpande
    • , Yongbo Peng
    • , Justin Louie
    • , Giorgio Lagna
    • , Ann C. Zovein
    •  & Akiko Hata
  • Article | | open

    The spindle matrix proteins, including Chro, are known to regulate mitotic spindle assembly in the cytoplasm. Here the authors show that in Drosophila larval brain, Chro promotes neural stem cell (NSC) reactivation and prevents activated NSCs from entering quiescence, and that Chro carries out such a role by regulating the expression of key transcription factors in the nucleus.

    • Song Li
    • , Chwee Tat Koe
    • , Su Ting Tay
    • , Angie Lay Keng Tan
    • , Shenli Zhang
    • , Yingjie Zhang
    • , Patrick Tan
    • , Wing-Kin Sung
    •  & Hongyan Wang
  • Article | | open

    The use of drug delivery systems for the gastrointestinal tract has been faced with a number of drawbacks related to their prolonged use. Here, the authors develop a drug-loaded hydrogel with high strength to withstand long-term gastrointestinal motility and can be triggered to dissolve on demand.

    • Jinyao Liu
    • , Yan Pang
    • , Shiyi Zhang
    • , Cody Cleveland
    • , Xiaolei Yin
    • , Lucas Booth
    • , Jiaqi Lin
    • , Young-Ah Lucy Lee
    • , Hormoz Mazdiyasni
    • , Sarah Saxton
    • , Ameya R. Kirtane
    • , Thomas von Erlach
    • , Jaimie Rogner
    • , Robert Langer
    •  & Giovanni Traverso
  • Article | | open

    Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescued by pharmacological inhibition of P300.

    • Jia Cao
    • , Jinghua Peng
    • , Hongying An
    • , Qiyi He
    • , Tatiana Boronina
    • , Shaodong Guo
    • , Morris F. White
    • , Philip A. Cole
    •  & Ling He
  • Article | | open

    The generation of glycolipid dolichylphosphate mannose (Dol-P-Man) is a critical step for protein glycosylation and GPI anchor synthesis. Here the authors report the structure of dolichylphosphate mannose synthase in complex with bound nucleotide and donor to provide insight into the mechanism of Dol-P-Man synthesis.

    • Rosaria Gandini
    • , Tom Reichenbach
    • , Tien-Chye Tan
    •  & Christina Divne
  • Article | | open

    The use of base editing enables precise genetic modifications in model animals. Here the authors show high efficient single-base editing in zebrafish using modified Cas9 and its VQR variant with an altered PAM specificity.

    • Yihan Zhang
    • , Wei Qin
    • , Xiaochan Lu
    • , Jason Xu
    • , Haigen Huang
    • , Haipeng Bai
    • , Song Li
    •  & Shuo Lin
  • Article | | open

    Synergistic use of coordination bonds that are strong and reversible realizes unique molecular recognition in artificial systems. Here, the authors show that a zinc-based metallomacrocyle can bind dicarboxylic acids of suitable length at specific metal sites by shape deformation and dimerization.

    • Takashi Nakamura
    • , Yuya Kaneko
    • , Eiji Nishibori
    •  & Tatsuya Nabeshima
  • Article | | open

    Transcription initiation by RNA polymerase III requires TFIIIB, a complex formed by Brf1/Brf2, TBP and Bdp1. Here, the authors describe the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter and characterize the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.

    • Jerome Gouge
    • , Nicolas Guthertz
    • , Kevin Kramm
    • , Oleksandr Dergai
    • , Guillermo Abascal-Palacios
    • , Karishma Satia
    • , Pascal Cousin
    • , Nouria Hernandez
    • , Dina Grohmann
    •  & Alessandro Vannini
  • Article | | open

    Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow.

    • David Stegner
    • , Judith M. M. vanEeuwijk
    • , Oğuzhan Angay
    • , Maximilian G. Gorelashvili
    • , Daniela Semeniak
    • , Jürgen Pinnecker
    • , Patrick Schmithausen
    • , Imke Meyer
    • , Mike Friedrich
    • , Sebastian Dütting
    • , Christian Brede
    • , Andreas Beilhack
    • , Harald Schulze
    • , Bernhard Nieswandt
    •  & Katrin G. Heinze
  • Article | | open

    Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to promote axon re-growth but how this is regulated is unclear. Here, the authors show that Wnt/β-catenin signaling in fibroblast-like cells at a lesion activates axon re-growth via deposition of Collagen XII.

    • Daniel Wehner
    • , Themistoklis M. Tsarouchas
    • , Andria Michael
    • , Christa Haase
    • , Gilbert Weidinger
    • , Michell M. Reimer
    • , Thomas Becker
    •  & Catherina G. Becker
  • Article | | open

    Endoplasmic reticulum (ER) stress promotes cardiac dysfunction. Here the authors uncover a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional repressor ZEB1, leading to induction of miR-183-5p and down-regulation of CHOP, and show that AGGF1 can effectively treat cardiac hypertrophy and heart failure.

    • Yufeng Yao
    • , Qiulun Lu
    • , Zhenkun Hu
    • , Yubin Yu
    • , Qiuyun Chen
    •  & Qing K. Wang
  • Article | | open

    Adding functional electronic components to graphene nanoribbons requires precise control over their atomic structure. Here, the authors use a bottom-up approach to build a metal-semiconductor junction and a tunnel barrier directly into a single graphene nanoribbon, an exciting development for graphene-based electronic devices

    • P. H. Jacobse
    • , A. Kimouche
    • , T. Gebraad
    • , M. M. Ervasti
    • , J. M. Thijssen
    • , P. Liljeroth
    •  & I. Swart
  • Article | | open

    The transcription factor Nkx2.5 is essential for heart development. Here, the authors identify a previously unknown expression domain for Nkx2.5 in the emu wing and explore its role in diminished wing bud development in the flightless emu, compared with three other birds that have functional wings.

    • Peter G. Farlie
    • , Nadia M. Davidson
    • , Naomi L. Baker
    • , Mai Raabus
    • , Kelly N. Roeszler
    • , Claire Hirst
    • , Andrew Major
    • , Mylene M. Mariette
    • , David M. Lambert
    • , Alicia Oshlack
    •  & Craig A. Smith
  • Article | | open

    Duchenne muscular dystrophy is a progressive degenerative disease of muscles caused by mutations in the dystrophin gene. Here the authors use AAV vectors to deliver microdystrophin to dogs with muscular dystrophy, and show restoration of dystrophin expression and reduction of symptoms up to 26 months of age.

    • Caroline Le Guiner
    • , Laurent Servais
    • , Marie Montus
    • , Thibaut Larcher
    • , Bodvaël Fraysse
    • , Sophie Moullec
    • , Marine Allais
    • , Virginie François
    • , Maeva Dutilleul
    • , Alberto Malerba
    • , Taeyoung Koo
    • , Jean-Laurent Thibaut
    • , Béatrice Matot
    • , Marie Devaux
    • , Johanne Le Duff
    • , Jack-Yves Deschamps
    • , Inès Barthelemy
    • , Stéphane Blot
    • , Isabelle Testault
    • , Karim Wahbi
    • , Stéphane Ederhy
    • , Samia Martin
    • , Philippe Veron
    • , Christophe Georger
    • , Takis Athanasopoulos
    • , Carole Masurier
    • , Federico Mingozzi
    • , Pierre Carlier
    • , Bernard Gjata
    • , Jean-Yves Hogrel
    • , Oumeya Adjali
    • , Fulvio Mavilio
    • , Thomas Voit
    • , Philippe Moullier
    •  & George Dickson
  • Article | | open

    Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.

    • Yufeng Yu
    • , Yong-Qiang Deng
    • , Peng Zou
    • , Qian Wang
    • , Yanyan Dai
    • , Fei Yu
    • , Lanying Du
    • , Na-Na Zhang
    • , Min Tian
    • , Jia-Nan Hao
    • , Yu Meng
    • , Yuan Li
    • , Xiaohui Zhou
    • , Jasper Fuk-Woo Chan
    • , Kwok-Yung Yuen
    • , Cheng-Feng Qin
    • , Shibo Jiang
    •  & Lu Lu
  • Article | | open

    Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.

    • Carolina Medina-Gomez
    • , John P. Kemp
    • , Niki L. Dimou
    • , Eskil Kreiner
    • , Alessandra Chesi
    • , Babette S. Zemel
    • , Klaus Bønnelykke
    • , Cindy G. Boer
    • , Tarunveer S. Ahluwalia
    • , Hans Bisgaard
    • , Evangelos Evangelou
    • , Denise H. M. Heppe
    • , Lynda F. Bonewald
    • , Jeffrey P. Gorski
    • , Mohsen Ghanbari
    • , Serkalem Demissie
    • , Gustavo Duque
    • , Matthew T. Maurano
    • , Douglas P. Kiel
    • , Yi-Hsiang Hsu
    • , Bram van der Eerden
    • , Cheryl Ackert-Bicknell
    • , Sjur Reppe
    • , Kaare M. Gautvik
    • , Truls Raastad
    • , David Karasik
    • , Jeroen van de Peppel
    • , Vincent W. V. Jaddoe
    • , André G. Uitterlinden
    • , Jonathan H. Tobias
    • , Struan F.A. Grant
    • , Pantelis G. Bagos
    • , David M. Evans
    •  & Fernando Rivadeneira
  • Article | | open

    The microscopic mechanism underlying an enhanced superconductivity in electron-doped iron selenide superconductor remains unclear. Here, Pan et al. report the spin excitations of Li0.8Fe0.2ODFeSe, revealing analogous momentum structure and dispersion to hole-doped cuprates.

    • Bingying Pan
    • , Yao Shen
    • , Die Hu
    • , Yu Feng
    • , J. T. Park
    • , A. D. Christianson
    • , Qisi Wang
    • , Yiqing Hao
    • , Hongliang Wo
    • , Zhiping Yin
    • , T. A. Maier
    •  & Jun Zhao
  • Article | | open

    To improve mechanical properties in ceramics through grain boundary engineering, precise mechanical characterization of individual boundaries is vital yet difficult to achieve. Here authors perform experiments using an in situ scanning electron microscopy based double cantilever beam test, allowing to directly view and measure stable crack growth in silicon carbide.

    • Giorgio Sernicola
    • , Tommaso Giovannini
    • , Punit Patel
    • , James R. Kermode
    • , Daniel S. Balint
    • , T. Ben Britton
    •  & Finn Giuliani
  • Article | | open

    Organizing photochromic molecules into 3D networks is a key strategy to access photoresponsive materials, but framework rigidity typically limits conversion efficiency. Here, the authors exploit a flexible metal-organic framework to achieve quantitative and reversible photoisomerization in a porous crystalline solid.

    • Yongtai Zheng
    • , Hiroshi Sato
    • , Pengyan Wu
    • , Hyung Joon Jeon
    • , Ryotaro Matsuda
    •  & Susumu Kitagawa