Browse Articles

  • Article | | open

    Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases metastasis in mouse xenograft models.

    • Hasini Jayatilaka
    • , Pranay Tyle
    • , Jonathan J. Chen
    • , Minsuk Kwak
    • , Julia Ju
    • , Hyun Ji Kim
    • , Jerry S. H. Lee
    • , Pei-Hsun Wu
    • , Daniele M. Gilkes
    • , Rong Fan
    •  & Denis Wirtz
  • Article | | open

    Device-independent self-testing is an approach that allows a complete certification of an unknown quantum state, simply by inspecting outcomes of measurements. Here, the authors demonstrate that any pure bipartite entangled state can be self-tested.

    • Andrea Coladangelo
    • , Koon Tong Goh
    •  & Valerio Scarani
  • Article | | open

    Both electronic and ionic transport must be optimized in Li4Ti5O12 for its use in Li-ion batteries, most promisingly against high voltage cathodes. Here authors synthesize hierarchical porous micrometre-scale structures composed of primary nanoparticles to demonstrate an attractive combination of rate performance, capacity and cycling stability.

    • Mateusz Odziomek
    • , Frédéric Chaput
    • , Anna Rutkowska
    • , Konrad Świerczek
    • , Danuta Olszewska
    • , Maciej Sitarz
    • , Frédéric Lerouge
    •  & Stephane Parola
  • Article | | open

    MxA (myxovirus resistance protein A) is a viral restriction factor whose activity depends on self-assembly into polymeric rings and helical filaments. Here the authors reveal the conformational movements involved in generating torque within polymeric MxA molecules and the dynamic conformational changes that occur upon GTP loading and hydrolysis.

    • Yang Chen
    • , Lei Zhang
    • , Laura Graf
    • , Bing Yu
    • , Yue Liu
    • , Georg Kochs
    • , Yongfang Zhao
    •  & Song Gao
  • Article | | open

    Targeted homologous recombination between parental chromosomes could facilitate precision breeding of crop plants. Here, Filler Hayut et al. show that CRISPR-Cas9 can be used to induce DNA double strand breaks in somatic tissue and achieve targeted recombination between homologs at an endogenous locus in tomato.

    • Shdema Filler Hayut
    • , Cathy Melamed Bessudo
    •  & Avraham A. Levy
  • Article | | open

    DNA-templated silver nanoclusters possess desirable optical properties, but their excited state dynamics remain poorly understood. Here the authors show that intracluster relaxations in such clusters are strongly coupled to a vibrational mode, resulting in ultrafast concerted transfer of population and coherence between excited states.

    • Erling Thyrhaug
    • , Sidsel Ammitzbøll Bogh
    • , Miguel R Carro-Temboury
    • , Charlotte Stahl Madsen
    • , Tom Vosch
    •  & Donatas Zigmantas
  • Article | | open

    Scalable and integratable sources of entangled-photon pairs are an important building block for quantum photonic applications. Here, Huber et al. demonstrate that droplet-etched gallium arsenide quantum dots can emit highly indistinguishable photon pairs with a high degree of entanglement.

    • Daniel Huber
    • , Marcus Reindl
    • , Yongheng Huo
    • , Huiying Huang
    • , Johannes S. Wildmann
    • , Oliver G. Schmidt
    • , Armando Rastelli
    •  & Rinaldo Trotta
  • Article | | open

    Lanthanide elements are difficult to separate from aqueous solution with low energy input. Here, the authors design a peptide that recognizes and drives the precipitation of an insoluble lanthanide complex under physiological conditions, introducing a biomineralization-based approach for rare earth recovery.

    • Takaaki Hatanaka
    • , Akimasa Matsugami
    • , Takamasa Nonaka
    • , Hideki Takagi
    • , Fumiaki Hayashi
    • , Takao Tani
    •  & Nobuhiro Ishida
  • Article | | open

    Quantitative characterization of supported nanomaterials is challenging, because the nanomaterial signals cannot easily be deconvoluted from those of the substrate. Here, the authors introduce an inventive approach to overcome this problem for electron-based surface analysis techniques.

    • Bo Da
    • , Jiangwei Liu
    • , Mahito Yamamoto
    • , Yoshihiro Ueda
    • , Kazuyuki Watanabe
    • , Nguyen Thanh Cuong
    • , Songlin Li
    • , Kazuhito Tsukagoshi
    • , Hideki Yoshikawa
    • , Hideo Iwai
    • , Shigeo Tanuma
    • , Hongxuan Guo
    • , Zhaoshun Gao
    • , Xia Sun
    •  & Zejun Ding
  • Article | | open

    Energy drain on micromechanical resonators is always compensated by energy gain from external sources during operation. Here, Chen et al. show a strategy that can sustain stable oscillations by redistributing mechanical energy between coupled vibrational modes when the external energy supply is off.

    • Changyao Chen
    • , Damián H. Zanette
    • , David A. Czaplewski
    • , Steven Shaw
    •  & Daniel López
  • Article | | open

    Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isolated populations

    • Lorraine Southam
    • , Arthur Gilly
    • , Dániel Süveges
    • , Aliki-Eleni Farmaki
    • , Jeremy Schwartzentruber
    • , Ioanna Tachmazidou
    • , Angela Matchan
    • , Nigel W. Rayner
    • , Emmanouil Tsafantakis
    • , Maria Karaleftheri
    • , Yali Xue
    • , George Dedoussis
    •  & Eleftheria Zeggini
  • Article | | open

    D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection with Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus to show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated vaccines.

    • Maria P. Cabral
    • , Patricia García
    • , Alejandro Beceiro
    • , Carlos Rumbo
    • , Astrid Pérez
    • , Miriam Moscoso
    •  & Germán Bou
  • Article | | open

    Epigenetic drugs are emerging as a powerful therapeutic option for cancer treatment. Here, the authors synthesized selective chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity and demonstrate their anti-tumour activity using in vitro and in vivo models of haematological neoplasia.

    • Edurne San José-Enériz
    • , Xabier Agirre
    • , Obdulia Rabal
    • , Amaia Vilas-Zornoza
    • , Juan A. Sanchez-Arias
    • , Estibaliz Miranda
    • , Ana Ugarte
    • , Sergio Roa
    • , Bruno Paiva
    • , Ander Estella-Hermoso de Mendoza
    • , Rosa María Alvarez
    • , Noelia Casares
    • , Victor Segura
    • , José I. Martín-Subero
    • , François-Xavier Ogi
    • , Pierre Soule
    • , Clara M. Santiveri
    • , Ramón Campos-Olivas
    • , Giancarlo Castellano
    • , Maite Garcia Fernandez de Barrena
    • , Juan Roberto Rodriguez-Madoz
    • , Maria José García-Barchino
    • , Juan Jose Lasarte
    • , Matias A Avila
    • , Jose Angel Martinez-Climent
    • , Julen Oyarzabal
    •  & Felipe Prosper
  • Article | | open

    It has been previously assumed that deep river channels could not have developed in the Proterozoic due to lack of vegetation. Here, the authors present remote sensing and outcrop data to show that large scale and deeply channelled river networks did exist in the Proterozoic despite the absence of vegetation.

    • Alessandro Ielpi
    • , Robert H. Rainbird
    • , Dario Ventra
    •  & Massimiliano Ghinassi
  • Article | | open

    IRE1? is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1?, inhibits both its kinase end RNase activities, and protects cells from apoptosis both in vitro and in vivo.

    • Decha Pinkaew
    • , Abhijnan Chattopadhyay
    • , Matthew D. King
    • , Preedakorn Chunhacha
    • , Zhihe Liu
    • , Heather L. Stevenson
    • , Yanjie Chen
    • , Patuma Sinthujaroen
    • , Owen M. McDougal
    •  & Ken Fujise
  • Article | | open

    Oesophageal squamous-cell carcinoma (ESCC) is a leading cause of cancer death, and half of ESCC cases occur in China. Here, the authors provide an in depth genomic landscape for this disease and identify specific mutation signatures—one of which is linked to alcohol intake.

    • Jiang Chang
    • , Wenle Tan
    • , Zhiqiang Ling
    • , Ruibin Xi
    • , Mingming Shao
    • , Mengjie Chen
    • , Yingying Luo
    • , Yanjie Zhao
    • , Yun Liu
    • , Xiancong Huang
    • , Yuchao Xia
    • , Jinlin Hu
    • , Joel S. Parker
    • , David Marron
    • , Qionghua Cui
    • , Linna Peng
    • , Jiahui Chu
    • , Hongmin Li
    • , Zhongli Du
    • , Yaling Han
    • , Wen Tan
    • , Zhihua Liu
    • , Qimin Zhan
    • , Yun Li
    • , Weimin Mao
    • , Chen Wu
    •  & Dongxin Lin
  • Article | | open

    Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeast S. cerevisiae to produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid reductase.

    • Tao Yu
    • , Yongjin J. Zhou
    • , Leonie Wenning
    • , Quanli Liu
    • , Anastasia Krivoruchko
    • , Verena Siewers
    • , Jens Nielsen
    •  & Florian David
  • Article | | open

    Scalable and integratable sources of entangled-photon pairs are an important building block for quantum photonic applications. Here, Keil et al. demonstrate that an ensemble of droplet-etched gallium arsenide quantum dots can emit polarization-entangled photons with almost 100% yield.

    • Robert Keil
    • , Michael Zopf
    • , Yan Chen
    • , Bianca Höfer
    • , Jiaxiang Zhang
    • , Fei Ding
    •  & Oliver G. Schmidt
  • Article | | open

    Constraining the timing of crustal processes and impact events remains challenging. Here, the authors show that atom probe tomography can produce highly accurate U-Pb isotopic age constraints in baddeleyite crystals, which is a common phase in terrestrial, Martian, Lunar and asteroidal materials.

    • L. F. White
    • , J. R. Darling
    • , D. E. Moser
    • , D. A. Reinhard
    • , T. J. Prosa
    • , D. Bullen
    • , D. Olson
    • , D. J. Larson
    • , D. Lawrence
    •  & I. Martin
  • Article | | open

    Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice.

    • Sandra M. Kallert
    • , Stephanie Darbre
    • , Weldy V. Bonilla
    • , Mario Kreutzfeldt
    • , Nicolas Page
    • , Philipp Müller
    • , Matthias Kreuzaler
    • , Min Lu
    • , Stéphanie Favre
    • , Florian Kreppel
    • , Max Löhning
    • , Sanjiv A. Luther
    • , Alfred Zippelius
    • , Doron Merkler
    •  & Daniel D. Pinschewer
  • Article | | open

    Spatial navigation and memory depend on neural coding of an organism’s location as well as large-scale knowledge of the environment, but how animals organize information in task-relevant spatial segments is not well understood. Here the authors show that, in rats, perirhinal neurons perform integrative operations, globally specifying where, in the task context, an animal is located.

    • Jeroen J. Bos
    • , Martin Vinck
    • , Laura A. van Mourik-Donga
    • , Jadin C. Jackson
    • , Menno P. Witter
    •  & Cyriel M. A. Pennartz
  • Article | | open

    Identifying pathways and transition states is critical to understanding chemical and biological reactions. Here, the authors introduce a capable computational approach using conformational space annealing to find multiple reaction pathways via global optimization of the Onsager-Machlup action.

    • Juyong Lee
    • , In-Ho Lee
    • , InSuk Joung
    • , Jooyoung Lee
    •  & Bernard R. Brooks
  • Article | | open

    The human congenital disorder Noonan Syndrome (NS) is caused by germ-line mutations that hyperactivate the RAS/ERK signalling pathway, and can feature pathologic cardiac enlargement. Here, the authors find that a complex cellular and molecular interplay involving a cytokine hierarchy underlies cardiac hypertrophy caused by a NS-associated Raf allele.

    • Jiani C. Yin
    • , Mathew J. Platt
    • , Xixi Tian
    • , Xue Wu
    • , Peter H. Backx
    • , Jeremy A. Simpson
    • , Toshiyuki Araki
    •  & Benjamin G. Neel
  • Article | | open

    Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis inhibition.

    • Justin Goodwin
    • , Michael L. Neugent
    • , Shin Yup Lee
    • , Joshua H. Choe
    • , Hyunsung Choi
    • , Dana M. R. Jenkins
    • , Robin J. Ruthenborg
    • , Maddox W. Robinson
    • , Ji Yun Jeong
    • , Masaki Wake
    • , Hajime Abe
    • , Norihiko Takeda
    • , Hiroko Endo
    • , Masahiro Inoue
    • , Zhenyu Xuan
    • , Hyuntae Yoo
    • , Min Chen
    • , Jung-Mo Ahn
    • , John D. Minna
    • , Kristi L. Helke
    • , Pankaj K. Singh
    • , David B. Shackelford
    •  & Jung-whan Kim
  • Article | | open

    Interfacing spin quantum memories with photons requires the controlled creation of defect centre—nanocavity systems. Here the authors demonstrate direct, maskless creation of single silicon vacancy centres in diamond nanostructures, and report linewidths comparable to naturally occurring centres

    • Tim Schröder
    • , Matthew E. Trusheim
    • , Michael Walsh
    • , Luozhou Li
    • , Jiabao Zheng
    • , Marco Schukraft
    • , Alp Sipahigil
    • , Ruffin E. Evans
    • , Denis D. Sukachev
    • , Christian T. Nguyen
    • , Jose L. Pacheco
    • , Ryan M. Camacho
    • , Edward S. Bielejec
    • , Mikhail D. Lukin
    •  & Dirk Englund