Browse Articles

  • Article | | open

    The majority of enzymatic Kemp elimination reactions proceed via a well-established acid-base mechanism. Here, the authors show that cytochrome P450 is able to metabolize the leflunomide drug via a redox Kemp elimination, offering new insights into enzyme catalysis.

    • Aitao Li
    • , Binju Wang
    • , Adriana Ilie
    • , Kshatresh D. Dubey
    • , Gert Bange
    • , Ivan V. Korendovych
    • , Sason Shaik
    •  & Manfred T. Reetz
  • Article | | open

    The transcription termination factor Rho is essential for growth in some bacteria but not in others. Here, Botella et al. show that Rho inactivation causes extensive pervasive transcription and loss of viability of the pathogen Mycobacterium tuberculosis both in vitro and in a mouse model of infection.

    • Laure Botella
    • , Julien Vaubourgeix
    • , Jonathan Livny
    •  & Dirk Schnappinger
  • Article | | open

    The analysis of site-specific glycosylation of HIV Envelope glycoprotein (Env) is challenging as it contains 25–30 glycosylation sites with multiple glycan forms at each site. Here the authors present a generally applicable mass spectrometry-based method for site-specific analysis of protein glycosylation that they apply to the analysis of the HIV-1 Env.

    • Liwei Cao
    • , Jolene K. Diedrich
    • , Daniel W. Kulp
    • , Matthias Pauthner
    • , Lin He
    • , Sung-Kyu Robin Park
    • , Devin Sok
    • , Ching Yao Su
    • , Claire M. Delahunty
    • , Sergey Menis
    • , Raiees Andrabi
    • , Javier Guenaga
    • , Erik Georgeson
    • , Michael Kubitz
    • , Yumiko Adachi
    • , Dennis R. Burton
    • , William R. Schief
    • , John R. Yates III
    •  & James C. Paulson
  • Article | | open

    Dust is an important nutrient source to landscapes, but often the source of dust is poorly constrained. Here, the authors quantify the origin of different dust sources in the Sierra Nevada by analysing dust composition and suggest exogenic dust may drive nutrient budgets in montane ecosystems.

    • S. M. Aciego
    • , C. S. Riebe
    • , S. C. Hart
    • , M. A. Blakowski
    • , C. J. Carey
    • , S. M. Aarons
    • , N. C. Dove
    • , J. K. Botthoff
    • , K. W. W. Sims
    •  & E. L. Aronson
  • Article | | open

    The gene-battery model posits transposable elements (TEs) may be cis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act as cis-regulatory modules in synergistic fashion.

    • Vasavi Sundaram
    • , Mayank N. K. Choudhary
    • , Erica Pehrsson
    • , Xiaoyun Xing
    • , Christopher Fiore
    • , Manishi Pandey
    • , Brett Maricque
    • , Methma Udawatta
    • , Duc Ngo
    • , Yujie Chen
    • , Asia Paguntalan
    • , Tammy Ray
    • , Ava Hughes
    • , Barak A. Cohen
    •  & Ting Wang
  • Article | | open

    Quantitative understanding of the spatial localization of hot carriers has been elusive. Here Cortes et al. spatially map hot-electron-driven reduction chemistry with 15 nm resolution as a function of time and electromagnetic field polarization for different plasmonic nanostructures.

    • Emiliano Cortés
    • , Wei Xie
    • , Javier Cambiasso
    • , Adam S. Jermyn
    • , Ravishankar Sundararaman
    • , Prineha Narang
    • , Sebastian Schlücker
    •  & Stefan A. Maier
  • Article | | open

    Gold catalysts have previously been reported for the epoxidation of alkenes with molecular oxygen. Here the authors show that, rather than the gold nanoparticles, the active species for this reaction are actually small, soluble gold species stabilized by the oxidised organic products.

    • Linping Qian
    • , Zhen Wang
    • , Evgeny V. Beletskiy
    • , Jingyue Liu
    • , Haroldo J. dos Santos
    • , Tiehu Li
    • , Maria do C. Rangel
    • , Mayfair C. Kung
    •  & Harold H. Kung
  • Article | | open

    Pathogens require iron for their metabolism and virulence. Here the authors identify an iron acquisition system in Pseudomonas aeruginosa involving a protein secreted by a type VI secretion system, the PQS signalling compound and siderophore receptors.

    • Jinshui Lin
    • , Weipeng Zhang
    • , Juanli Cheng
    • , Xu Yang
    • , Kaixiang Zhu
    • , Yao Wang
    • , Gehong Wei
    • , Pei-Yuan Qian
    • , Zhao-Qing Luo
    •  & Xihui Shen
  • Article | | open

    Understanding inter-individual differences in stress-susceptibility could lead to novel treatments and preventative strategies for stress-related pathologies. Here the authors provide evidence that increased endocannabinoid signalling is a resilience factor that buffers against adverse consequences of stress.

    • Rebecca J. Bluett
    • , Rita Báldi
    • , Andre Haymer
    • , Andrew D. Gaulden
    • , Nolan D. Hartley
    • , Walker P. Parrish
    • , Jordan Baechle
    • , David J. Marcus
    • , Ramzi Mardam-Bey
    • , Brian C. Shonesy
    • , Md. Jashim Uddin
    • , Lawrence J. Marnett
    • , Ken Mackie
    • , Roger J. Colbran
    • , Danny G. Winder
    •  & Sachin Patel
  • Review Article | | open

    The continued search of high-performance semiconductors for organic electronics calls for smart molecular designs. Here, Ying et al. review the recent development of synthesizing regioregular narrow bandgap conjugated polymers and the effect of regioregularity on transistor and photovoltaic performance.

    • Lei Ying
    • , Fei Huang
    •  & Guillermo C. Bazan
  • Article | | open

    Localized surface plasmon resonances induce strong modifications of surface-enhanced Raman spectra. Here the authors propose a robust method to retrieve the fingerprint of intrinsic chemical information by using the photoluminescence of the metallic structures to correct the spectra.

    • Kai-Qiang Lin
    • , Jun Yi
    • , Jin-Hui Zhong
    • , Shu Hu
    • , Bi-Ju Liu
    • , Jun-Yang Liu
    • , Cheng Zong
    • , Zhi-Chao Lei
    • , Xiang Wang
    • , Javier Aizpurua
    • , Rubén Esteban
    •  & Bin Ren
  • Article | | open

    Efficient therapeutic strategies to target mutant-p53 cancers are needed. Here, the authors demonstrate the molecular mechanism through which mutant-p53 tumours are susceptible to oxidative damage and propose a potential strategy for targeting such cancers by inhibiting the SLC7A11-glutathione axis.

    • David S. Liu
    • , Cuong P. Duong
    • , Sue Haupt
    • , Karen G. Montgomery
    • , Colin M. House
    • , Walid J. Azar
    • , Helen B. Pearson
    • , Oliver M. Fisher
    • , Matthew Read
    • , Glen R. Guerra
    • , Ygal Haupt
    • , Carleen Cullinane
    • , Klas G. Wiman
    • , Lars Abrahmsen
    • , Wayne A. Phillips
    •  & Nicholas J. Clemons
  • Article | | open

    Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane region.

    • Weikang Cai
    • , Masaji Sakaguchi
    • , Andre Kleinridders
    • , Gonzalo Gonzalez-Del Pino
    • , Jonathan M. Dreyfuss
    • , Brian T. O’Neill
    • , Alfred K. Ramirez
    • , Hui Pan
    • , Jonathon N. Winnay
    • , Jeremie Boucher
    • , Michael J. Eck
    •  & C. Ronald Kahn
  • Article | | open

    Zika virus infection can cause human birth defects and Guillain-Barré syndrome. Here the authors present the structures of the full-length nonstructural protein 5 and its RNA-dependent RNA polymerase domain of Zika virus, which are targets for inhibitors of virus replication.

    • Baoyu Zhao
    • , Guanghui Yi
    • , Fenglei Du
    • , Yin-Chih Chuang
    • , Robert C. Vaughan
    • , Banumathi Sankaran
    • , C. Cheng Kao
    •  & Pingwei Li
  • Article | | open

    Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.

    • Xusheng Wang
    • , Haiyan Chen
    • , Ruiyun Tian
    • , Yiling Zhang
    • , Marina S. Drutskaya
    • , Chengmei Wang
    • , Jianfeng Ge
    • , Zhimeng Fan
    • , Deqiang Kong
    • , Xiaoxiao Wang
    • , Ting Cai
    • , Ying Zhou
    • , Jingwen Wang
    • , Jinmei Wang
    • , Shan Wang
    • , Zhihai Qin
    • , Huanhuan Jia
    • , Yue Wu
    • , Jia Liu
    • , Sergei A. Nedospasov
    • , Edward E. Tredget
    • , Mei Lin
    • , Jianjun Liu
    • , Yuyang Jiang
    •  & Yaojiong Wu
  • Article | | open

    Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.

    • Zuqiang Liu
    • , Roshni Ravindranathan
    • , Pawel Kalinski
    • , Z. Sheng Guo
    •  & David L. Bartlett
  • Article | | open

    Recently, fabrication processes have realised three-dimensional nanoporous graphene. Here, the authors reveal two-dimensional Dirac plasmons in three-dimensional nanoporous graphene disclosing strong plasmonic absorptions tunable from terahertz to mid-infrared via controllable doping level and porosity.

    • Fausto D’Apuzzo
    • , Alba R. Piacenti
    • , Flavio Giorgianni
    • , Marta Autore
    • , Mariangela Cestelli Guidi
    • , Augusto Marcelli
    • , Ulrich Schade
    • , Yoshikazu Ito
    • , Mingwei Chen
    •  & Stefano Lupi
  • Article | | open

    Peking-type and PI 88788-type soybeans are both used as sources of resistance against soybean cyst nematode. Here the authors show that in contrast to PI 88788-type resistance, where GmSNAP18 acts in combination with two neighbouring genes, in Peking-type resistance GmSNAP18 acts with GmSHMT08 to confer resistance.

    • Shiming Liu
    • , Pramod K. Kandoth
    • , Naoufal Lakhssassi
    • , Jingwen Kang
    • , Vincent Colantonio
    • , Robert Heinz
    • , Greg Yeckel
    • , Zhou Zhou
    • , Sadia Bekal
    • , Johannes Dapprich
    • , Bjorn Rotter
    • , Silvia Cianzio
    • , Melissa G. Mitchum
    •  & Khalid Meksem
  • Article | | open

    The recent outbreak of Zika virus is a major worldwide health concern and effective drugs are currently not available. Here the authors present the structure of Zika non-structural protein 5 and identify a potential drug-binding site, which might facilitate the development of novel antivirals.

    • Boxiao Wang
    • , Xiao-Feng Tan
    • , Stephanie Thurmond
    • , Zhi-Min Zhang
    • , Asher Lin
    • , Rong Hai
    •  & Jikui Song
  • Article | | open

    Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.

    • Zhentao Zhang
    • , Obiamaka Obianyo
    • , Elfriede Dall
    • , Yuhong Du
    • , Haian Fu
    • , Xia Liu
    • , Seong Su Kang
    • , Mingke Song
    • , Shan-Ping Yu
    • , Chiara Cabrele
    • , Mario Schubert
    • , Xiaoguang Li
    • , Jian-Zhi Wang
    • , Hans Brandstetter
    •  & Keqiang Ye
  • Article | | open

    Direct conversion of esters to amides, while attractive, is often limited to activated esters or highly nucleophilic amines. Here the authors report a nickel-catalysed reductive coupling between unactivated esters and nitroarenes, giving a direct route to aromatic amides.

    • Chi Wai Cheung
    • , Marten Leendert Ploeger
    •  & Xile Hu
  • Article | | open

    The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the design of non-nucleoside polymerase inhibitors.

    • Andre S. Godoy
    • , Gustavo M. A. Lima
    • , Ketllyn I. Z. Oliveira
    • , Naiara U. Torres
    • , Fernando V. Maluf
    • , Rafael V. C. Guido
    •  & Glaucius Oliva