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Current vaccines are less efficient in preventing infection. Here, the authors show that an intranasal vaccine (DelNS1-RBD) based on a live attenuated influenza virus induces robust levels of neutralizing antibodies and T cells and prevents replication of SARS-CoV-2 Delta and Omicron variants in respiratory tissues.
Percutaneous spinal cord epidural stimulation (SCES) leads were implanted in two men with spinal cord injury (SCI) in an approved trial by the McGuire IRB committee. SCES decreased the assistance required from the exoskeleton. In one participant, SCES enabled standing and stepping in parallel bars and overground ambulation with a walker.
Indirect reciprocity describes how cooperation arises in a community when its members value their reputation. Here, the authors show that nuanced assessments of observations can mitigate disagreements and errors when the opinions of community members are not synchronized.
Plasma neurodegeneration biomarkers are increasingly utilized to predict neurological disease. Here, authors show in different neurological disorders associations between plasma neurodegeneration biomarker concentrations and various measures of glymphatic and meningeal lymphatic functions.
By exploiting unique properties of both diabolic and exceptional points in the spectrum of non-Hermitian systems, the authors propose an experimental scheme of a programmable multimode switch, which opens alternative routes for light manipulations.
CRISPR-regulated toxin-antitoxin (CreTA), safeguards CRISPR-Cas immune systems. Here the authors characterize a bacterial CreTA and use this to generate a proof-of-concept antimicrobial strategy, ATTACK, which associates TA and CRISPR-Cas to kill multidrug resistant pathogens.
Using a mouse model harboring a WHIM Syndrome-linked gain-of-function CXCR4 mutation and bone marrow samples from WHIM patients, the authors show that proper CXCR4 signaling termination is essential for bone tissue homeostasis.
Recapitulating the native architecture of myocardium is crucial to engineering functional cardiac tissues. Here, the authors develop a leaf-venation-directed strategy for macroscale cardiac constructs with tissue-like structural, mechanical, and electrophysiological properties.
Here, in a cohort of 772 women undergoing triple-negative breast cancer (TNBC) therapy, the authors show that antimicrobial prescription during TNBC treatment associates with inferior overall and breast cancer-specific survival, in turn related to peripheral lymphocyte count and gut microbiome dysbiosis.
Fragmentation-induced fluidization occurs in concentrated pyroclastic density currents where rapid particle breakage causes flow compaction and subsequent high pore fluid pressure, reducing friction and explaining their long runout.
Some materials can display magnetic order despite having spin-singlet ground state on individual magnetic sites. This arises due to exchange interactions mixing excited crystal electric field states. Here, Gao et al study and example of such a system, Ni2Mo3O8, and find that crystal electric field states in both the paramagnetic and antiferromagnetic states exhibit dispersive excitations.
Although the importance of thymic epithelial cells (TEC) in thymus physiology is established, the development of functionally diverse TEC populations remains incompletely understood. Here, using fate-mapping experiments in the embryonic thymus, the authors identify keratin19+ multipotent progenitor cells that support medullary TEC diversity in adulthood.
Cation cross-over affects CO2 electroreduction process, yet the detailed effect, especially the cation effect in promising membrane electrode assemblies, needs further investigation. Here the authors reveal that unintentional cation crossover through anion exchange membranes during CO2 electrolysis influences product selectivity towards carbon monoxide or ethylene.
Achieving controllable fine-tuning of defects is desired for electrocatalysts. Here, the authors present a facile and controllable thermal tuning strategy that enables fine control of nanodefects, thereby endowing common carbon materials with high electrocatalytic oxidation efficiency.
The Southern Atlantic-Southwest Indian ridges hold mid-ocean ridge basalts with a residual subduction-related geochemical signature, whose origin is unsolved. The study suggests a link to a subduction-modified mantle transported inland >2280 km by a large-scale flat slab event.
Kinetic Alfven Waves (KAWs) are ubiquitous in space plasmas. Here, the authors show that application of particle sounding technique to Magnetospheric Multiscale Mission data enables measuring perpendicular wavelength of KAWs.
Clustering of earthquake magnitudes is actively debated. Here, the authors show statistically significant magnitude clustering present in many different field and laboratory catalogs at a wide range of spatial scales (mm to 1000 km).
The potential of thermoelectric devices is typically hindered by heat stagnation and poor mechanical strength, which degrade their performance. Here, the authors demonstrate larger temperature gradients and higher mechanical strength by developing 3D core-shell architected thermoelectric devices.
The dysfunction of IL-10 secreting regulatory B cells has been linked to the pathogenesis of autoimmune disease. Here the authors show that low dose IL-2 therapy can enhance IL-10 production in regulatory B cell populations via the modulation of BACH2.