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Microbial heparin bioproduction is hampered by the difficulty of recombinant expression of active heparan sulfate N-deacetylase/N-sulfotransferase. Here, the authors solve the problem by developing a cellular system-based semisynthetic strategy and achieve the production of active heparin by engineered E. coli.
Accurate mapping of strain distribution calls for strain sensor arrays with high sensitivity, high sensing density and inter-unit consistency. Here, the authors report an array made from ordered assembly of monodispersed spiky carbon nanospheres to achieve the above features simultaneously.
The authors realize composite optimization in dielectric tunable materials by simultaneously achieving low electric field, large tunability, and low loss through ion substitution design in ferroelectric tunable materials.
Temperature and absolute humidity are associated with influenza activity, and recent data from Hong Kong have suggested ozone as an additional environmental driver. Here, the authors investigate the relationship between ozone and influenza transmission using surveillance data from the USA and find evidence for an inhibitory effect.
Researchers test geodynamic models for far-field continental deformation during the Laramide orogeny. New and existing thermal data show that the hot hinterland crust promoted lower crust mobility and crust-mantle decoupling during flat-slab traction.
Here, the authors observed significant genetic correlation of GlycA with lung function, asthma and COPD and identified ten shared loci revealing potential shared biological mechanisms involving ubiquitination and Wnt/β-catenin signaling.
Interaction with surrounding lumina leads to potential medical risks in transluminal procedures. Here, the authors report a magnetic steering continuum robot that achieve autonomous shaping without the need for environmental interaction.
Decarbonizing the European ammonia industry: Less stringent emissions caps for electrolytic hydrogen production can significantly reduce costs and land use while still achieving more than 90% reduction in emissions relative to fossil-based hydrogen.
L-shaped silicon metamaterials are realized exhibiting broadband and enhanced chirality. The current work sets new benchmarks in the assembly of ultrathin dielectric chiral metamaterials that can efficiently control chiral light-matter interactions.
Plants initiate specific defense responses by recognizing flg22 peptide epitope derived from flagellin, the major structural protein of the bacterial flagellum. Here, the authors identified two plant subtilases, SBT5.2 and SBT1.7, as specific proteases responsible for cleaving the peptide epitope.
Abbe’s diffraction limit has been a defining concept for microscopy. With finite photon, photon noise remains one essential factor yet to be considered in the theoretical resolution limit. Here, the authors introduced information-based resolution limit allowing for photon-considered resolution assessment of various microscopy and super-resolution modalities.
Molecular isomerization in solution is dependent on coupling of solute and solvent via memory-dependent friction. Here, by applying memory kernel extraction to molecular dynamics simulations, the authors demonstrate the role of friction in determining isomerization kinetics.
Finding an optimal shape for transport networks, represented as multilayer structures, is a challenging problem. The authors propose analytical and computational frameworks to analyze sharp transitions from symmetric to asymmetric shapes in optimal networks, that can be applied for planning and development of improved multimodal transportation systems within a city.
In pelvic inflammatory disease, host immune responses to Neisseria gonorrhoeae damage Fallopian tube tissue and cause infertility. Here, Garcia et al. show that the cytokine IL-17C induces inflammatory responses, and peptidoglycan fragments reduce transcripts related to tissue integrity.
Photochromic materials suffer from degradation when exposed to harsh chemical environments, but this can be overcome by providing chemical shielding via superomniphobicity. Here, the authors show the design rationale and careful materials selection for fabrication of color morphing surfaces that can simultaneously display excellent chemical resistance.
The fast-spinning primary of the Didymos near-earth asteroid binary system was found to have a degraded top shape by the DART (NASA) mission. Here, authors find that these surface features observed in the asteroid are more likely to have been caused by collisional effects than by the YORP effect.
Arteriovenous fistulas are the most common vascular access points for hemodialysis, but they have a high incidence of postoperative dysfunction, mainly due to excessive neointimal hyperplasia. Here, the author shows that LncDACH1 regulates NIH through the HSP90/ SRPK1/ AKT signaling axis.
Copy number alterations in stem cells impair neural crest differentiation and set the stage for neuroblastoma-like traits and tumours. This study hints at early tumourigenesis mechanisms and finds developmental gene signatures linked to prognosis.
Here, Dillard and Taft-Benz et al. show in a female mouse model how different adjuvants affect inactivated vaccine-mediated protection against homologous SARS-CoV-2 and heterologous SARS-CoV-1-like coronaviruses. They find that an aluminum hydroxide-adjuvanted vaccine can increase risk of adverse outcomes during heterologous infection.