Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationBrief Communication
Ureide catabolism in Arabidopsis thaliana and Escherichia coli
Andrea K Werner, Tina Romeis & Claus-Peter Witte
Published online: 22 November 2009 | doi:10.1038/nchembio.265
Allantoin catabolism provides nitrogen, carbon and energy for several species, but the biochemical route to these resources in some species was unclear. A multidimensional bioinformatic search across organisms has now led to the identification of two enzymes that complete the degradation pathway.
Abstract - Ureide catabolism in : Arabidopsis thaliana: and : Escherichia coli | Full Text - Ureide catabolism in Arabidopsis thaliana and Escherichia coli | PDF (359 KB) - Ureide catabolism in Arabidopsis thaliana and Escherichia coli | Supplementary information | Chemical compounds
Articles
Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria
Eric C Carnes, DeAnna M Lopez, Niles P Donegan, Ambrose Cheung, Hattie Gresham, Graham S Timmins & C Jeffrey Brinker
Published online: 22 November 2009 | doi:10.1038/nchembio.264
Quorum sensing refers to a signaling mechanism allowing the behavior of bacterial populations to be coordinated based on cell density. Physical isolation of individual bacterial cells revealed that a single bacterium can respond to quorum sensing signals resulting in genetic reprogramming and enhanced.
Abstract - Confinement-induced quorum sensing of individual : Staphylococcus aureus: bacteria | Full Text - Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria | PDF (630 KB) - Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria | Supplementary information
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence
Holger Gerlach, Vanessa Laumann, Sascha Martens, Christian F W Becker, Roger S Goody & Matthias Geyer
Published online: 22 November 2009 | doi:10.1038/nchembio.268
Binding of HIV-1 Nef to host cell membranes is a biphasic process that involves electrostatic curvature-sensitive Nef-lipid interactions followed by a slower formation of an amphipathic helix. Nef action on the membrane may promote curvature and subsequent endocytosis of the host-cell proteins.
Abstract - HIV-1 Nef membrane association depends on charge, curvature, composition and sequence | Full Text - HIV-1 Nef membrane association depends on charge, curvature, composition and sequence | PDF (1,032 KB) - HIV-1 Nef membrane association depends on charge, curvature, composition and sequence | Supplementary information | Chemical compounds
Automatic policing of biochemical annotations using genomic correlations
Tzu-Lin Hsiao, Olga Revelles, Lifeng Chen, Uwe Sauer & Dennis Vitkup
Published online: 22 November 2009 | doi:10.1038/nchembio.266
Errors in functional annotations can cause significant problems in later research. A new method to identify misannotations by analyzing the genomic context correlations corrects these errors, such as in the reassignment of genes now demonstrated to have roles in leucine and fatty acid degradation.
Abstract - Automatic policing of biochemical annotations using genomic correlations | Full Text - Automatic policing of biochemical annotations using genomic correlations | PDF (489 KB) - Automatic policing of biochemical annotations using genomic correlations | Supplementary information | Chemical compounds
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Chemical Biology advance online publication, day month year (doi:10.1038/nchembioXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Chemical Biology volume, page (year); advance online publication, (doi:10.1038/nchembioXXXXX)".
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