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Antitoxins

Therapy for stressed bacteria

Bacteria oscillate between the planktonic and biofilm states through many hierarchically organized networks that respond to environmental cues. Recent research describes how a bacterial toxin-antitoxin system mediates this transition by controlling bacterial motility in response to extracellular stress.

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Figure 1: MqsA modulates RpoS activity and thereby the switch between biofilm and motility.

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Correspondence to Scott J Hultgren.

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The authors declare no competing financial interests.

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Hadjifrangiskou, M., Kostakioti, M. & Hultgren, S. Therapy for stressed bacteria. Nat Chem Biol 7, 345–347 (2011). https://doi.org/10.1038/nchembio.584

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