Because of the large number of phospholipids, their highly active metabolism and our lack of understanding of protein-lipid specificity, lipid signaling is a particularly challenging subject to study. Help might come from new tools that will allow us to follow and manipulate lipids and lipid-binding proteins in living cells.
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References
Kholodenko, B.N., Hoek, J.B. & Westerhoff, H.V. Trends Cell Biol. 10, 173–178 (2000).
Ejsing, C.S. et al. Proc. Natl. Acad. Sci. USA 106, 2136–2141 (2009).
Brown, H.A. & Murphy, R.C. Nat. Chem. Biol. 5, 602–606 (2009).
Várnai, P. & Balla, T. Methods 46, 167–176 (2008).
Oatey, P.B. et al. Biochem. J. 344, 511–518 (1999).
Martelli, A.M. et al. Cell. Signal. 18, 1101–1107 (2006).
Szentpetery, Z., Balla, A., Kim, Y.J., Lemmon, M.A. & Balla, T. BMC Cell Biol. 10, 67 (2009).
Várnai, P. & Balla, T. Biochim. Biophys. Acta 1761, 957–967 (2006).
Maffucci, T. & Falasca, M. FEBS Lett. 506, 173–179 (2001).
Neef, A.B. & Schultz, C. Angew. Chem. Int. Ed. Engl. 48, 1498–1500 (2009).
Agard, N.J., Prescher, J.A. & Bertozzi, C.R. J. Am. Chem. Soc. 126, 15046–15047 (2004).
Leung, T.H., Hoffmann, A. & Baltimore, D. Cell 118, 453–464 (2004).
Lemmon, M.A. Nat. Rev. Mol. Cell Biol. 9, 99–111 (2008).
Varnai, P., Thyagarajan, B., Rohacs, T. & Balla, T. J. Cell Biol. 175, 377–382 (2006).
Abe, N., Inoue, T., Galvez, T., Klein, L. & Meyer, T. J. Cell Sci. 121, 1488–1494 (2008).
Inoue, T. & Meyer, T. PLoS ONE 3, e3068 (2008).
Jiang, T. et al. J. Biol. Chem. 273, 11017–11024 (1998).
Dinkel, C., Moody, M., Traynor-Kaplan, A.E. & Schultz, C. Angew. Chem. Int. Ed. Engl. 40, 3004–3008 (2001).
Schultz, C. Bioorg. Med. Chem. 11, 885–898 (2003).
Laketa, V. et al. Chem. Biol. 16, 1190–1196 (2009).
Subramanian, D. et al. Nat. Chem. Biol. 6, 324–326 (2010).
Ozaki, S., DeWald, D.B., Shope, J.C., Chen, J. & Prestwich, G.D. Proc. Natl. Acad. Sci. USA 97, 11286–11291 (2000).
Alessi, D.R. et al. Curr. Biol. 7, 261–269 (1997).
Balla, T. Trends Endocrinol. Metab. 16, 289–290 (2005).
Krylova, I.N. et al. Cell 120, 343–355 (2005).
Li, Y. et al. Mol. Cell 17, 491–502 (2005).
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Schultz, C. Challenges in studying phospholipid signaling. Nat Chem Biol 6, 473–475 (2010). https://doi.org/10.1038/nchembio.389
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DOI: https://doi.org/10.1038/nchembio.389