The level of an individual protein in cells treated with combinations of drugs is best explained by simple linear superposition of the protein levels in response to single drugs. This finding may facilitate rational design of higher order drug combinations.
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Dixon, S., Stockwell, B. Engineering drug combinations. Nat Chem Biol 6, 318–319 (2010). https://doi.org/10.1038/nchembio.353
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DOI: https://doi.org/10.1038/nchembio.353
