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Grand Challenge Commentary: The chemistry of a dynamic genome

Nature Chemical Biology volume 6, pages 866–868 (2010)Cite this article

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In the postsequencing era, chemical biology is uniquely situated to investigate genomic DNA alterations arising through epigenetic modifications, genetic rearrangements or active mutation. These transformations significantly expand nature's diversity and may profoundly alter our view of DNA's coding potential.

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Figure 1: The dynamic genome.

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  1. Rahul M. Kohli is in the Division of Infectious Disease in the Department of Medicine, and the Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.,

    Rahul M Kohli

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  1. Rahul M Kohli
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Correspondence to Rahul M Kohli.

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Kohli, R. Grand Challenge Commentary: The chemistry of a dynamic genome. Nat Chem Biol 6, 866–868 (2010). https://doi.org/10.1038/nchembio.471

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