In This Issue - pv

doi:10.1038/nchembio0506-v

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Keeping chemistry in the equation - p223

doi:10.1038/nchembio0506-223

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The integration of cell and chemical biology in protein folding - pp224 - 227

Jeffery W Kelly & William E Balch

doi:10.1038/nchembio0506-224

Eukaryotic cells are specialized, interdependent functional units of complex tissues that are composed of metabolically integrated systems defined by chemically distinct organelles that operate as reaction vessels. It is now clear that the small-molecule and polymer-based composition of these organelles plays a crucial role in generating and maintaining protein folds and functions through the systems chemistry of the local environments.

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Fishing and frogging for anti-angiogenic drugs - pp228 - 229

Frederik De Smet, Peter Carmeliet & Monica Autiero

doi:10.1038/nchembio0506-228

There is a growing medical need for additional anti-angiogenic drugs. A new model of regenerative angiogenesis in the fin of adult zebrafish promises to accelerate discovery of genes and drugs related to angiogenesis.

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See also: Article by Bayliss et al.

Metalloproteases see the light - pp229 - 230

Matthew Bogyo

doi:10.1038/nchembio0506-229

Small-molecule probes that chemically tag targets by virtue of their enzymatic activities offer a means to focus system-wide experiments and provide functional information for entire families of proteins. Recent advances in the design and application of light-activated probes that target metalloproteases have created the opportunity to study this medically important family of enzymes in unprecedented detail.

Full Text - Metalloproteases see the light | PDF (134 KB) - Metalloproteases see the light

See also: Article by Sieber et al.

A library of RNA bridges - pp231 - 232

Ning Gao & Joachim Frank

doi:10.1038/nchembio0506-231

Translation starts with the assembly of the ribosome from its subunits, which requires the formation of intersubunit bridges. A combinatorial mutagenesis approach has now identified a number of the 16S rRNA residues involved in intersubunit bridging that are functionally important for the ribosome.

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See also: Letter by Rackham et al.

Remarkable structural variation within fatty acid megasynthases - pp232 - 234

John E Cronan

doi:10.1038/nchembio0506-232

The crystal structures of two chain-building megasynthases, the fatty acid synthases of mammals and fungi, have recently been reported. Although both are composed of modules derived from the discrete enzymes that catalyze bacterial fatty acid synthesis, the two synthases have dramatically different architectures.

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Redox sensing and histidine oxidation: no longer PerR-fect strangers - pp234 - 235

W Scott Moye-Rowley

doi:10.1038/nchembio0506-234

Oxidation of cysteine residues is a well-described means of sensing oxidative stress. Analysis of a bacterial transcriptional repressor protein indicates that metal-catalyzed oxidation of histidine residues can provide oxidative stress control in a cysteine-independent fashion.

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Research Highlights - p237

doi:10.1038/nchembio0506-237

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