Small-molecule probes that chemically tag targets by virtue of their enzymatic activities offer a means to focus system-wide experiments and provide functional information for entire families of proteins. Recent advances in the design and application of light-activated probes that target metalloproteases have created the opportunity to study this medically important family of enzymes in unprecedented detail.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ghaemmaghami, S. et al. Nature 425, 737–741 (2003).
Sieber, S.A., Niessen, S., Hoover, H.S. & Cravatt, B.F. Nat. Chem. Biol. 2, 274–281 (2006).
Berger, A.B., Vitorino, P.M. & Bogyo, M. Am. J. Pharmacogenomics 4, 71–81 (2004).
Jessani, N. & Cravatt, B.F. Curr. Opin. Chem. Biol. 8, 54–59 (2004).
Speers, A.E. & Cravatt, B.F. ChemBioChem 5, 41–47 (2004).
Jeffery, D.A. & Bogyo, M. Curr. Opin. Biotechnol. 14, 87–95 (2003).
Saghatelian, A., Jessani, N., Joseph, A., Humphrey, M. & Cravatt, B.F. Proc. Natl. Acad. Sci. USA 101, 10000–10005 (2004).
López-Otín, C. & Overall, C.M. Nat. Rev. Mol. Cell Biol. 3, 509–519 (2002).
Overall, C.M. & Kleifeld, O. Nat. Rev. Cancer 6, 227–239 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bogyo, M. Metalloproteases see the light. Nat Chem Biol 2, 229–230 (2006). https://doi.org/10.1038/nchembio0506-229
Issue Date:
DOI: https://doi.org/10.1038/nchembio0506-229
