Translation starts with the assembly of the ribosome from its subunits, which requires the formation of intersubunit bridges. A combinatorial mutagenesis approach has now identified a number of the 16S rRNA residues involved in intersubunit bridging that are functionally important for the ribosome.
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Ribosomal small subunit domains radiate from a central core
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References
Frank, J. et al. Biochem. Cell Biol. 73, 757–765 (1995).
Yusupov, M.M. et al. Science 292, 883–896 (2001).
Gao, H. et al. Cell 113, 789–801 (2003).
Schuwirth, B.S. et al. Science 310, 827–834 (2005).
Gao, N. et al. Mol Cell. 18, 663–674 (2005).
Rackham, O. & Chin, J.W. Nat. Chem. Biol. 2, 254–258 (2006).
Frank, J. & Agrawal, R.K. Nature 406, 318–322 (2000).
Valle, M. et al. Cell 114, 123–134 (2003).
Carter, A.P. et al. Science 291, 498–501 (2001).
Maivali, U. & Remme, J. RNA 10, 600–604 (2004).
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Gao, N., Frank, J. A library of RNA bridges. Nat Chem Biol 2, 231–232 (2006). https://doi.org/10.1038/nchembio0506-231
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DOI: https://doi.org/10.1038/nchembio0506-231
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Ribosomal small subunit domains radiate from a central core
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