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Biosynthesis

SAM cycles up for colibactin

Nature Chemical Biology volume 13, pages 1059–1061 (2017)Cite this article

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The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

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Figure 1: SAM is both an aminobutaryl donor and a precursor of cyclopropyl groups.

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  1. Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA

    Steven G Van Lanen

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  1. Steven G Van Lanen
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Correspondence to Steven G Van Lanen.

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Van Lanen, S. SAM cycles up for colibactin. Nat Chem Biol 13, 1059–1061 (2017). https://doi.org/10.1038/nchembio.2479

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