Hydrogen peroxide regulates cell signaling pathways through oxidation of specific thiol proteins. A new study describes a relay system involving peroxiredoxin 2 as a peroxide sensor that oxidizes the mammalian transcription factor STAT3 via a mixed disulfide intermediate.
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Winterbourn, C., Hampton, M. Signaling via a peroxiredoxin sensor. Nat Chem Biol 11, 5–6 (2015). https://doi.org/10.1038/nchembio.1722
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DOI: https://doi.org/10.1038/nchembio.1722
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