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Letter

Nature Chemical Biology 1, 154–158 (1 August 2005) | doi:10.1038/nchembio720

Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine

Douglas A Mitchell & Michael A Marletta

Nitric oxide (NO) signaling through the formation of cGMP is well established; however, there seems to be an increasing role for cGMP-independent NO signaling. Although key molecular details remain unanswered, S-nitrosation represents an example of cGMP-independent NO signaling.