Protein nitrosation is an important signaling mechanism in vivo; however, mechanisms for selective nitric oxide modification of cysteines have not been described. Thioredoxin is now shown to rapidly and site-specifically catalyze S-nitrosation of an active site cysteine of caspase-3.
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References
Hess, D.T. et al. Nat. Rev. Mol. Cell Biol. 6, 150–166 (2005).
Lane, P. et al. Sci. STKE 2001, RE1 (2001).
Jaffrey, S.R. et al. Nat. Cell Biol. 3, 193–197 (2001).
Mitchell and Marletta Nat. Chem. Biol. 1, 154–158 (2005).
Dedon, P.C. & Tannenbaum, S.R. Arch. Biochem. Biophys. 423, 12–22 (2004).
Li, J. et al. Biochem. Biophys. Res. Commun. 240, 419–424 (1997).
Zhang, Y. & Hogg, N. Free Radic. Biol. Med. 38, 831–838 (2005).
Mannick, J.B. et al. Science 284, 651–654 (1999).
Haendeler, J. et al. Nat. Cell Biol. 4, 743–749 (2002).
Nikitovic, D. & Holmgren, A. J. Biol. Chem. 271, 19180–19185 (1996).
Liu, L. et al. Nature 410, 490–494 (2001).
Singh, S.D. et al. Proc. Natl. Acad. Sci. USA 93, 14428–14433 (1996).
Kim, J. & Tannenbaum, S.R. J. Biol. Chem. 279, 9758–9764 (2003).
Saitoh, M. et al. EMBO J. 17, 2596–2606 (1998).
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Tannenbaum, S., Kim, JE. Controlled S-nitrosation. Nat Chem Biol 1, 126–127 (2005). https://doi.org/10.1038/nchembio0805-126
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DOI: https://doi.org/10.1038/nchembio0805-126
