Despite their potential as drugs, peptides are generally not cell permeable, which limits their practical applications in medicine. Now, linear peptides have been cyclized by using a heteroaromatic linker. This cyclization both improves passive membrane permeability and stabilizes a biologically relevant secondary structure.
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Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides
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Saito, F., Bode, J. Tying up loose ends. Nature Chem 8, 1085–1086 (2016). https://doi.org/10.1038/nchem.2683
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DOI: https://doi.org/10.1038/nchem.2683
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Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides
Nature Communications (2018)