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Nucleic acid hybridization

Robust sequence discrimination

Nature Chemistry volume 4, pages 155–157 (2012)Cite this article

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Careful consideration of thermodynamics has allowed the design of nucleic acid probes that are highly specific and virtually unaffected by changes in reaction conditions.

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Figure 1: Toehold exchange hybridization.

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Authors and Affiliations

  1. Grégoire Altan-Bonnet is in the Computational Biology Program at the Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA,

    Grégoire Altan-Bonnet

  2. Fred Russell Kramer is at the New Jersey Medical School, Public Health Research Institute, 225 Warren Street, Newark, New Jersey 07103, USA,

    Fred Russell Kramer

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  1. Grégoire Altan-Bonnet
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  2. Fred Russell Kramer
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Correspondence to Grégoire Altan-Bonnet or Fred Russell Kramer.

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Altan-Bonnet, G., Kramer, F. Robust sequence discrimination. Nature Chem 4, 155–157 (2012). https://doi.org/10.1038/nchem.1283

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