Bioanalytical chemistry


Bioanalytical chemistry is a subdiscipline of analytical chemistry that involves the separation, detection, identification and quantification of biological samples in different settings. It often involves the study of molecules such as proteins, peptides, DNA and drugs.

Latest Research and Reviews

News and Comment

  • News and Views |

    A method for directly probing binding interactions in free solution, without the need for chemical tagging, offers exciting opportunities for non-perturbative analyses of biomolecules in their native state.

    • Enrique Valera
    •  & Ryan C. Bailey
    Nature Chemistry 7, 767–769
  • News and Views |

    An electrochemical clamp assay that enables the rapid and sensitive detection of nucleic acids containing single base mutations has now been developed. It has been shown to differentiate between cancer patient samples featuring a specific mutation, and controls from healthy donors or other cancer patients, all directly in unprocessed serum.

    • Irina A. Gorodetskaya
    •  & Alon A. Gorodetsky
    Nature Chemistry 7, 541–542
  • News and Views |

    An extracellular ejection of zinc, known as a zinc spark, is triggered by the fertilization of a mammalian egg; however, the origin of this zinc was not clear. Now, a combination of four complementary techniques has revealed the source and provided an unprecedented quantification of the distribution of zinc in a maturing mammalian oocyte.

    • Kyle P. Carter
    •  & Amy E. Palmer
    Nature Chemistry 7, 96–97
  • News and Views |

    Therapeutic drug monitoring is vital for maintaining drug concentrations within the body in real time, maximizing therapeutic effects while minimizing the risk of harmful overdosing or wasteful underdosing. Semisynthetic fusion proteins now provide a straightforward strategy for drug monitoring by simply taking a picture of glowing paper.

    • Lei Ge
    •  & Jinghua Yu